^<31>P-MR Spectroscopy of Experimental Tumors Following Irradiation

フォーマット

• 論文(リポジトリ)

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Ohkubo, Masaki ; Sakai, Kunio ; Fujita, Shozo ; Itoh, Takeshi ; Higuchi, Takeshi ; Higuchi, Shoichi ; Kimura, Motomasa ; Yuasa, Tatsuhiko

出版情報

• Niigata University School of Medicine , 1992-03

掲載情報

• Acta medica et biologica— Acta medica et biologica

ISSN

• 05677734

著者名

• Ohkubo, Masaki
• Sakai, Kunio
• Fujita, Shozo
• Itoh, Takeshi
• Higuchi, Takeshi
• Higuchi, Shoichi
• Kimura, Motomasa
• Yuasa, Tatsuhiko

巻

• 40

号

• 1

開始ページ

• 29

終了ページ

• 34

概要

• Phosphorus-31 magnetic resonance spectra were obtained by the JEOL JMN-GX270 spectrometer (6.3T) using the JEOL NM-G27TSPW surface coil probe from transplanted FM3A tumors grown subcutaneously in C3H mice at 3 h, 8 h, 1 day and 2 days after ^<60>CO irradiation with a single dose of 20 Gy or of 40 Gy. As there was no statistically significant difference between volumes of the tumors irradiated with 20 Gy and those with 40 Gy up to 3 days after irradiation, it is suggested that the observed changes in ^<31>P-MR spectra were due to a metabolic response to radiation,not due to the differences of tumor volumes. We found occasionally marked decreases in NTP levels at 3-8h after irradiation, which recovered 1-2 days later. Those changes, however, had no direct relation to later tumor growth. On the other hand, relative sequential changes observed from the 1st to the 2nd day, which included intracellular pHi of the tumor, Pi/β-NTP and PME/β-NTP ratios determined from ^<31>P-MR spectra, were related to later tumor growth. In responding tumors, those relative sequential changes showed increased pHi, decreased Pi/β-NTP and PME/β-NTP ratios, while reverse changes were found in control and non-responding tumors. It was concluded that relative sequential changes of those parameters could be used for predicting in early stages the tumor response to radiotherapy.

本文リンク

• http://hdl.handle.net/10191/33374
  

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