1.
論文(リポジトリ) |
福田, 稔 ; 宮沢, しのぶ ; 安保, 徹
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2.
論文(リポジトリ) |
福田, 稔 ; 宮沢, しのぶ ; 安保, 徹
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3.
論文(リポジトリ) |
皆川, 昌広 ; 大矢, 洋 ; 清水, 孝王 ; 坂内, 誠 ; 安保, 徹 ; 畠山, 勝義
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4.
論文(リポジトリ) |
川村, 俊彦 ; 安保, 徹
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5.
論文(リポジトリ) |
福田, 稔 ; 安保, 徹
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6.
論文(リポジトリ) |
小川, 充 ; 安保, 徹
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7.
論文(リポジトリ) |
佐藤, 万成 ; 山際, 訓 ; 長谷川, 勝彦 ; 大塚, 和朗 ; 桑名, 謙治 ; 小方, 則夫 ; 高橋, 達 ; 朝倉, 均 ; 上村, 朝輝 ; 橋本, 誠雄 ; 安保, 徹
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8.
論文(リポジトリ) |
福田, 稔 ; 安保, 徹
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9.
論文(リポジトリ) |
山際, 訓 ; 菅原, 聡 ; 良田, 裕平 ; 朝倉, 均 ; 武者, 信行 ; 渡部, 久美 ; 安保, 徹
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10.
論文(リポジトリ) |
福田, 稔 ; 小林, 弘多 ; 安保, 徹
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11.
論文(リポジトリ) |
福田, 稔 ; 安保, 徹
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12.
論文(リポジトリ) |
諸田, 哲也 ; 鈴木, 晋 ; 塚原, 明弘 ; 多々, 孝 ; 安保, 徹 ; 飯合, 恒夫 ; 畠山, 勝義
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13.
論文(リポジトリ) |
相田, 純久 ; 安保, 徹
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14.
論文(リポジトリ) |
福田, 稔 ; 安保, 徹
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15.
論文(リポジトリ) |
安保, 徹
概要:
There exists a considerable number of unique T lymphocytes in the periphery in congenitally athymic nude mice, and in ag
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ed humans and animals with the involuted thymus. It is, therefore, suggested by several investigators that the extrathymic pathway of T cell differentiation may be present somewhere. We have recently demonstrated that such extrathymic T cell differentiation occurs in the hepatic sinusoids in humans and mice. This pathway of T cell differentiation resides phylogenetically earlier than the intrathymic pathway of T cell differentiation. Before and after thymic development, extrathymic T cells might work as the surveillance system for atypical cells generated in vivo by virture of their autoreactivity. Extrathymic T cells have α β TcR (and γ δ TcR) of intermediate intensity and contain many autoreactive T cell clones. The existence of the hepatic pathway could clearly explain the phenomenon “breakdown of self-tolerance”, and occupies an important position of the immunology for aging, autoimmine disease, malignancy, bacterial infection, transplantation and allergy (immediate hypersensitivity).
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16.
論文(リポジトリ) |
安保, 徹
概要:
One of the purpose of "the introduction of Medicine" is, I believe, that you can feel the spirit of medicine and would like medicine more. The other is that you become moral doctors. Now, I think why doctor's morality has become a social
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problem. Just because many present doctors haven't understood how the autonomic nervous system controls host defense and over-reacts to it. If we care and cure patients without this knowledge, we will make them worse. And the more efforts we make, the more patients and people complain.
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17.
論文(リポジトリ) |
橋本, 誠雄 ; 鳥羽, 健 ; 青木, 定夫 ; 岸, 賢治 ; 高橋, 益広 ; 小池, 正 ; 柴田, 昭 ; 品田, 章二 ; 安保, 徹
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18.
論文(リポジトリ) |
渡部, 久実 ; 飯合, 恒夫 ; 安保, 徹
概要:
Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells
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were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity.
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19.
論文(リポジトリ) |
小川, 充 ; 飯合, 恒夫 ; 安保, 徹
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20.
論文(リポジトリ) |
安保, 徹
概要:
Genetic background and microenvironmental factors are highly responsible for the onset of autoimmune diseases. However, the effector lymphocytes, which attack directly the living tissues, are also an important factor to think about the
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mechanisms involved in the onset of diseases. How these effector lymphocytes increase in the number in patients with autoimmune diseases, and what kinds of properties in these cells lead to the onset of diseases? To date, extrathymic T cells and CD5^+B cells are focused attention as such the effector cells. Herein, these cells will be dealed as a central subject to be introduced, and the mechanisms involved in the onset of diseases will be discussed.
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21.
論文(リポジトリ) |
小川, 充 ; 飯合, 恒夫 ; 安保, 徹
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22.
論文(リポジトリ) |
小川, 充 ; 飯合, 恒夫 ; 渡部, 久実 ; 安保, 徹
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23.
論文(リポジトリ) |
安保, 徹
概要:
The existence of extrathymically differentiated T cells was recently demonstrated by us and other investigators. The subsequent studies revealed that the sits where such extrathymic T cells are differentiated include the hepatic
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sinusoids and intraepithelial sites in the intestine. Especially, extrathymic T cells generated in the liver appear even in the organs other than the liver when they are activated. They may act rationally as a surveillance system against abnormal self, and sometimes seem to induce certain autoimmune diseases when they are over-activated. In this study, we have investigated detailed sites of extrathymic T-cell differentiation in the liver and their subsequent movements by using normal mice, congenitally athymic nude mice and autoimmune MRL-lpr/lpr mice (human SLE model).
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