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1.

論文(リポジトリ)

論文(リポジトリ)
R.M.A., CHAMIKA ; Kobayashi, Keiko ; Narita, Taichi ; Saito, Tomoko
出版情報: 新潟大学保健学雑誌 — 新潟大学保健学雑誌.  13  pp.11-17,  2016-09.  新潟大学医学部保健学科
本文リンク: http://hdl.handle.net/10191/44138
概要: Lifestyle and health behavior are known risk factors for non-communicable diseases (NCD), and they can\naffect quality o f life (QOL). University students are future decision makers in institutions, societies, and countries. Thus,\nthe objectives of this study were to examine the reality of the lifestyles, health behaviors, and QOL of university students\nand to clarify the relationship between their health behaviors and QOL. The sample was 199 students at “A” University,\nin grades of first-year to fourth-year during the academic year 2014–15. A self-administered questionnaire assessed the\ndemographic variables, health statuses, lifestyles, health behaviors, and QOL of the students. The amount of time spent\nwatching television was higher among students living alone. Female students had higher amounts of study time and a\ngreater prevalence for adequate sleep (7–8 hours) than their counterparts. Regular exercise was higher among male\nstudents. Alcohol consumption and smoking were higher among male students, and students living with families ate\nbreakfast regularly. There was weak positive correlation between WHO Quality of Life-BREF and Breslow’s health\nhabits. This study showed that effective health education that considered differences of gender and family condition is especially relevant for the promotion of their health because the QOL at this phase of development creates a foundation for health and QOL in late adulthood. 続きを見る
2.

学位論文(リポジトリ)

学位
Maruyama, Katsuya
出版情報: 2017-03-23.  新潟大学
本文リンク: http://hdl.handle.net/10191/47573
概要: The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires. FACT-G and FACT-P scores were significantly decreased; however, the absolute change after 60 months was minimal. The transient decreases in the Trial Outcome Index (TOI) score returned to their baseline levels. Use of ADT, presence of adverse events, and biochemical failure were related to lower scores. Scores of subdomains of FACT instruments indicated characteristic changes. The pattern of HRQOL change after C-ion RT was similar to that of other modalities. Further controlled studies focusing on a HRQOL in patients with prostate cancer are warranted.<br />学位の種類: 博士(医学). 報告番号: 甲第4242号. 学位記番号: 新大院博(医)甲第720号. 学位授与年月日: 平成29年3月23日<br />The Journal of Radiation Research 58(2)260-266,2017<br />新大院博(医)甲第720号 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
Kobayashi, Makoto ; Suda, Takeshi ; Hashiba, Masao ; Nagasaki, Koji ; Adachi, Aiko ; Nomoto, Minoru ; Arakawa, Masaaki ; Aoyagi, Yutaka
出版情報: Acta medica et biologica — Acta medica et biologica.  56  pp.1-9,  2008-03.  Niigata University School of Medicine
本文リンク: http://hdl.handle.net/10191/19590
概要: Limitations to physical activity lead to impairments of insulin sensitivity and deterioration of health related quality of life (HRQOL) in patients with chronic liver diseases (CLD). The effects of regular exercise on physical and psychosocial factors were prospectively evaluated in CLD. Five patients with various etiologies and stages were enrolled. Daily aerobic and resistance trainings were conducted for a course of five months with an oral intake of branched-chain amino acids (BCAA) starting one month prior to the exercise. Various biochemical, physical parameters, and profile of mood states (POMS) were measured before and after the course. Statistical significance was evaluated using a resampling method. No event was marked during the course to require additional treatments. A significant improvement in insulin sensitivity was observed as reductions of fasting blood glucose and serum insulin levels. Physical capability was significantly improved in both strength and endurance as increments of grasping and knee extension powers, and ventilatory threshold. The fatigue score was significantly reduced in accordance with a decreasing tendency of all other negative aspects in POMS. While significant decreases in serum concentrations of cholinesterase and prealbumin, platelet count, and bone mass were observed, serum concentrations of transferrin and BCAA as well as prothrombin activity showed increasing tendency. Regular exercise could be a promising alternative to improve insulin sensitivity and HRQOL in CLD, though medications and close evaluation should be conducted for possibilities of osteoporosis and hemorrhagic events. 続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
FURUKAWA, Koichi ; WATANABE, Kazuhiko ; ABE, Yukihiro ; AIBA, Tuneo ; IKARASHI, Kentarou ; HATA, Koujiro ; Ho, Nichau ; TSUKIOKA, Satosi
出版情報: Acta medica et biologica — Acta medica et biologica.  53  pp.73-77,  2005-09.  Niigata University School of Medicine
本文リンク: http://hdl.handle.net/10191/1916
概要: To evaluate outpatient treatment, as well as the clinical effect of 1M tegafur-0.4M gimestat-1M otastat potassium(S-1) f ollowed by weekly Paclitaxel(PTX) for patients with far advanced inoperable gastric cancer, we analyzed retrospectively the appropriateness of outpatient anticancer chemotherapy from the standards of overall survival and time without symptom and toxicity(TWiST) as a quality-adjusted survival analysis. A total of 18 patients with advanced inoperable gastric cancer were treated with S-1 as first line single-agent chemotherapy from May 1, 2000 to September 30, 2000 at the Niigata City General Hospital. S-1 (60mg-120mg/m^2/orally twice daily on Days 1-28 followed by a 14 days rest/course) was repeated until progression of the disease. After the first line was completed, a second line, PTX (60mg-80mg/m^2/infused on Day 1/week, three weeks and withdrawal for a week), was started two weeks later. PTX was repeated until progression of the disease. No severe adverse events (≧National Cancer Institute Common Toxicity Criteria ((NCICTC) grade 3) were observed. The median survival time (MST) overall including the first line and second line was 295 days. The hospitalization period was 60.0 days throughout the median of the total hospital stay and the rate was 25.6% in overall survival. There was no significant difference by histological type, metastasis, liver metastasis, or peritoneal dissemination. The median duration of TWiST as quality-adjusted survival analysis was 353 days in good performance status (PS) and 72 days in poor PS. S-1 followed by weekly PTX for various advanced inoperable gastric cancers appears to be a promising, appropriate, and well-tolerated anticancer chemotherapy regimen in an outpatient setting. 続きを見る
5.

学位論文(リポジトリ)

学位
Sakai, Sayuri
出版情報: pp.1-18,  2015-03-23.  新潟大学
本文リンク: http://hdl.handle.net/10191/32281
概要: Background: Minamata disease (MD) is caused by the ingestion of a large amount of fish or shellfish contaminated with Me Hg included in industrial wastewater. In 1965, a number of cases were found along the Agano River in Niigata Prefecture in northern central Japan, which were collectively designated as “Niigata Minamata disease.” Patients with MD suffer from a set of complicated pains accompanied by various signs and symptoms. They also have mental and social pains, including loss of identity, stigmatization that lead leads to the refusal of friendship and marriage, and isolation in the local community. However, few studies have investigated the care and prevention measures required to relieve the symptoms of patients with MD. Aim: The objective of this survey was to investigate the symptoms, pain, and suffering experienced by patients with Niigata Minamata disease as well as their QOL and coping strategies. Design and setting: The survey was designed as a complete study of patients with MD accessible to the local government of Niigata Prefecture and that City. Results: The average score of the study subjects in the World Health Organization Quality of Life 26 (WHO/QOL-26) was considerably lower than that of the general population, while being female and having an occupation correlated with higher scores for some domains and/or overall QOL scores. The symptoms perceived by the subjects distressing in their daily lives included numbness in limbs, physical pain, disturbed sensory systems, limb dysfunctions, and fatigability. The measures commonly taken to relieve these symptoms included using medicines, taking a bath/going to springs, and maintaining warmth. The common emotional support included interpersonal relationships, emotional fulfillment, self-discipline in daily life, and bodily health. Those certified as having MD showed no significant difference in any domains and overall QOL. Conclusions: Palliative care providers should extend their targets for non-cancer palliative care and develop approaches for MD-specific total pain.<br />学位の種類: 博士(医学). 報告番号: 甲第3997号. 学位記番号: 新大院博(医)甲第643号. 学位授与年月日: 平成27年3月23日<br />新大院博(医)甲第643号 続きを見る