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1.

論文(リポジトリ)

論文(リポジトリ)
安保, 徹
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  108  pp.173-177,  1994-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38110
概要: Genetic background and microenvironmental factors are highly responsible for the onset of autoimmune diseases. However, the effector lymphocytes, which attack directly the living tissues, are also an important factor to think about the mechanisms involved in the onset of diseases. How these effector lymphocytes increase in the number in patients with autoimmune diseases, and what kinds of properties in these cells lead to the onset of diseases? To date, extrathymic T cells and CD5^+B cells are focused attention as such the effector cells. Herein, these cells will be dealed as a central subject to be introduced, and the mechanisms involved in the onset of diseases will be discussed. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
安保, 徹
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  108  pp.83-90,  1994-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38057
概要: The existence of extrathymically differentiated T cells was recently demonstrated by us and other investigators. The subsequent studies revealed that the sits where such extrathymic T cells are differentiated include the hepatic sinusoids and intraepithelial sites in the intestine. Especially, extrathymic T cells generated in the liver appear even in the organs other than the liver when they are activated. They may act rationally as a surveillance system against abnormal self, and sometimes seem to induce certain autoimmune diseases when they are over-activated. In this study, we have investigated detailed sites of extrathymic T-cell differentiation in the liver and their subsequent movements by using normal mice, congenitally athymic nude mice and autoimmune MRL-lpr/lpr mice (human SLE model). 続きを見る