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1.

論文(リポジトリ)

論文(リポジトリ)
渡部, 久実 ; 飯合, 恒夫 ; 安保, 徹
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.425-429,  1993-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37391
概要: Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
大森, 克利
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  106  pp.1129-1137,  1992-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/40235
概要: The thymus is the major central organ for T cell differentiation in the body. However attention was recently focused on an association of extrathymic T cells with various immune response. The liver is a major site for such extrathymic T cell differentiation. Cumulative evidences revealed that extrathymic T cells in the liver comprise cells with TCR of intermediate intensity and contain autoreactive clones. These extrathymic T cells were activated with aging and under conditions of bacterial stimulation and autoimmune diseases. In the present study, it was investigated how regular T cells were activated in mice injected with viable syngeneic tumors. It was demonstrated that specific activation of extrathymic T cells in the liver and acquisition of anti-tumor cytotoxicity were induced in these mice. The present results suggested that extrathymic T cells played an important role on tumor immunity in the host-defense mechanisms. 続きを見る