CD56陽性T細胞の特徴
- フォーマット:
- 論文(リポジトリ)
- 責任表示:
- 橋本, 誠雄
- 出版情報:
- 新潟医学会, 1994-05
- 掲載情報:
- 新潟医学会雑誌 — 新潟医学会雑誌
- ISSN:
- 00290440
- 著者名:
- 橋本, 誠雄
- 巻:
- 108
- 通号:
- 5
- 開始ページ:
- 358
- 終了ページ:
- 366
- 概要:
- In a series of recent studies, extrathymic T cell differentiation in mice has been reported. These T cells may be more primitive than that of thymic origin. Since they carry self reactive forbidden clones, it could be benefical for elimenating their own atypical cells. They express IL-2Rβ similar to NK cells, containing CD4 or CD8 double negative cells. Their morphology is large granular lymphocyte (LGL). This study is to elucidate the possibility that CD56 … positive T cells with a morphology of LGL are the counterpart of extrathymic T cells in human. CD56 positive T cells were abundant in the liver comparing in peripheral blood from same donor. The phenotype of T cells in the liver mononuclear cells (MNC), CD56 positive T cells had considerably higher proportion of TCR-γδ aquisition, and CD4, CD8 double negative population were also existed in one of the case who had high population of CD56 positive T cells. While CD56 positive cells were absent in the thymus. CD56 positive T cells were able to proliferate in serum-rich medium condition supplemented with IL-2. CD56 positive T cells were also harvested from bone marrow cells in a liquid culture without thymic environment. These results described above and similarities of the extrathymic T cells in mice, strongly indicate the possibility that CD56 positive T cells is a counterpart of extrathymic T cells in humans. 続きを見る
- E-Resources:
類似資料:
新潟大学医学部 |
新潟医学会 |
新潟医学会 | |
新潟医学会 |
新潟医学会 |
新潟医学会 |
新潟医学会 |
新潟医学会 |
新潟医学会 |
新潟医学会 |
新潟医学会 |