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論文(リポジトリ) |
論文(リポジトリ)
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岡田, 正彦
概要:
Vascular disorder is the major cause of death. In this paper, we call this disease state as arteriosclerosis. In order to prevent the disease, it is essential to predict possible risk factors and to eliminate them. High blood
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pressure and hyper-cholesteremia are well-known examples of such risk factors. Also some kinds of stress such as salt intake and cigarette smoking increase the vasomotor tone which decreases arterial distensibility. Low distensibility of the arteial wall is possibly a risk factor of arteriosclerosis, and is detectable by measuring the arterial pulse wave velocity. The first step to the prevention of the arteriosclerosis is to develop various kinds of laboratory tests for detecting the risk factors. And storing laboratory data for a long period of time is also necessary step toward the purpose. We have to develop not only the database of test results but also the storage of laboratory specimens such as serum of healthy subjects. The retrospective analyses of the archive will bring us an important hint to determine the criteria, by which we can predict who will suffer from the disease in the future.
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| 2.
論文(リポジトリ) |
論文(リポジトリ)
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岡田, 正彦
概要:
In this paper, we discuss the recent theory of pathogenesis of atherosclerosis. Endothelial cells of the vascular wall play an important role for controlling vascular tone, preventing thrombus formation, exchanging substances between
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blood and tissues, and so on. The increased level of low density lipoprotein (LDL), especially modified LDL will cause migration of monocyte-macrophages into sub-endothelial area. Modified LDL is taken up by the macrophages, which become form cells. Smooth muscle cells contribute to this process as well. These events are thought to be main parts in the pathogenesis of atherosclerosis. Some kinds of modifications of LDL, i.e. , oxidative modification of LDL, are also essential part of it. Shear stress which is caused by blood flow can accelerate the process.
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