1.
図書 |
edited by Masaaki Arakawa, Fumiake Gejyo
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図書 |
荒川正昭
目次情報:
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3.
論文(リポジトリ) |
荒川, 正昭
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4.
論文(リポジトリ) |
西堀, 武明 ; 牧野, 真人 ; 川崎, 聡 ; 村山, 直也 ; 塚田, 弘樹 ; 長谷川, 隆志 ; 五十嵐, 謙一 ; 鈴木, 榮一 ; 荒川, 正昭 ; 下条, 文武 ; 尾崎, 京子
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5.
論文(リポジトリ) |
荒川, 正昭
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6.
論文(リポジトリ) |
斎藤, 功 ; 長谷川, 有香 ; 原田, 隆 ; 大渕, 雄子 ; 広瀬, 慎太郎 ; 黒田, 毅 ; 長谷川, 隆志 ; 中野, 正明 ; 鈴木, 栄一 ; 荒川, 正昭
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7.
論文(リポジトリ) |
大澤, 治章 ; 山岸, 豪 ; 長谷川, 尚 ; 小幡, 八郎 ; 椙谷, 博也 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 中野, 正明 ; 荒川, 正昭
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8.
論文(リポジトリ) |
佐藤, 健比呂 ; 渡辺, 武 ; 長谷川, 尚 ; 中野, 正明 ; 荒川, 正昭
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9.
論文(リポジトリ) |
西浦, 智子 ; 首村, 守俊 ; 若杉, 三奈子 ; 黒田, 毅 ; 高田, 俊範 ; 伊藤, 聡 ; 中野, 正明 ; 荒川, 正昭 ; 桃井, 明仁 ; 馬場, 靖幸 ; 朝倉, 均
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10.
論文(リポジトリ) |
村上, 修一 ; 本田, 茂 ; 大渕, 雄子 ; 伊藤, 聡 ; 中野, 正明 ; 荒川, 正昭
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11.
論文(リポジトリ) |
成田, 一衛 ; 近藤, 大介 ; 永井, 雅昭 ; 中山, 均 ; 後藤, 真 ; 竹田, 徹朗 ; 坂爪, 実 ; 斉藤, 亮彦 ; 中川, 洋一 ; 荒川, 正昭
概要:
In order to elucidate the molecular mechanisms, in which acute and basically selflimited glomerular injury advance to ch
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ronic and progressive glomerulosclerosis, we tried to identify genes expressed predominantly in the kidney of chronic and progressive glomerulosclerosis but less in acute and transient glomerulonephritis. Progressive glomerulosclerosis was induced in male Sprague-Dawley rats by unilateral nephrectomy followed by monoclonal anti-Thy1. 1 antibody (OX-7) injection (Nx). Control rats were sham operated and injected with OX’7 (Sham) to induce acute and transient glomerulonephritis. Urinary protein measurement and morphological examinations were performed until 6 months after the disease induction. In Nx rats, proteinuria increased with time and mesangial expansion was accompanied by interstitial fibrosis, whereas, in Sham rats, transient proteinuria peaked at 1 week and mesangiolysis was followed by mesangial hypercellularity which was dissolved spontaneously after 4 weeks. Four weeks after the induction of the chronic (Nx) and acute(Sham)glomerulonephritis, before any remarkable histological difference between both groups was evident, mRNAs were isolated from kidney cortex of the groups and used for cDNA synthesis. By subtraction hybridization of cDNAs from Nx with an excess amount of those from Sham, We isolated and characterized several genes expressed predominantly in the Nx group. These included genes that encode serine protease inhibitors, ligands for cytokines, osteopontin, and those for de novo protein synthesis as well as those with unknown function. Osteopontin expression was immunohistologically found to be upregulated in Nx at 4 weeks after the disease induction, whereas no remarkable expression was found in the Sham group. In conclusion, we have identified genes expressed predominantly in chronic glomerulosclerosis but less in acute glomerulonephritis. These genes may play important roles in the process which promotes initial glomerular injury to result in chronic and progressive glomerulosclerosis.
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12.
論文(リポジトリ) |
西, 慎一 ; 荒川, 正昭
概要:
Chronic glomerulonephritis (CGN) is a major cause of end stage renal diseases in our country. Recently the number of pat
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ients with CGN is gradually increasing according to the increase of national population. The mean age of patients is also elevating related to the change of social constitution of national generations. The treatment CGN contains various medical and social problems. We have treated the patients with CGN for long time using steroid and/or immunosuppressive agents, however, these agents have adverse effects, especially to the highly aged patients. In this paper we discussed the results of our protocol treatments and the prospect for the new treatment program in the future.
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13.
論文(リポジトリ) |
江村, 巌 ; 張, 高明 ; 今井, 洋介 ; 柿原, 敏夫 ; 石黒, 卓朗 ; 内藤, 眞 ; 吉沢, 弘久 ; 荒川, 正昭
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14.
論文(リポジトリ) |
長谷川, 隆志 ; 鈴木, 栄一 ; 荒川, 正昭 ; 下条, 文武
概要:
There are variable clinical forms in allergic occupational lung diseases not only due to the variety of the inhaled anti
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gens but also due to anatomical structure of the lung. Almost inhaled antigens were trapped in upper respiratory tract, and the others reached into lower respiratory tract and alveolar space depend upon their pore size and velocity of the inspiration. Bronchial’ asthma arid hypersensitivity pneumonia are important entities in the management of allergic occupational lung diseases. Careful past and present history in the respect of the relation to the occupational environment with patients are necessary in the diagnosis of these two diseases, although other conventional examination such as chest X-ray and hemato-biochemistrical analysis should be performed.
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15.
論文(リポジトリ) |
小浦方, 啓代 ; 斎藤, 功 ; 市川, 卓郎 ; 真島, 一郎 ; 片桐, 敦子 ; 村松, 芳幸 ; 荒川, 正昭 ; 塚田, 浩治
概要:
A 48 year-old woman was admitted because of diarrhea, insomnia and general fatigue which had not been changed with antidiarrheic, sleeping pill, antidepressant and autogenic training. She was diagnosed irritable bowel
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syndrome, autonomic imbalance with anxiety and chronic thyroiditis with euthyroid function. She was given intravenous infusion therapy of 1000ml 5% glucose and finished fasting therapy using the method of Touhoku University with diary and psychotherapy. After that she was treated with antidepressant and levothyroxine. Her symptoms were improved gradually after fasting therapy.
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16.
論文(リポジトリ) |
片桐, 敦子 ; 真島, 一郎 ; 村松, 芳幸 ; 荒川, 正昭 ; 下条, 文武 ; 齋藤, 功 ; 桜井, 浩治
概要:
Autogenes Training is a medical treatment that is used with psychosomatic medicine. This Training is self-relxation. After all, that is medical treatment or protection against patients of psychosomatic disease and neurosis. This time,
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we explain a purpose of Autogenes Training. Then, we explain this measure. We report that a patient of irritable colon syndrome was healed by this medical treatment.
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17.
論文(リポジトリ) |
村松, 芳幸 ; 村松, 公美子 ; 小浦方, 啓代 ; 真島, 一郎 ; 片桐, 敦子 ; 荒川, 正昭 ; 下条, 文武 ; 櫻井, 浩治
概要:
Tranzactional Analysis was created by Eric Berne (psychiatrist) in America in 1957. The theory of tranzactional analysis contained four kinds of analysis (structual analysis, tranzactional analysis, game analysis and script analysis),
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is based on psychoanalysis theory, and do it easily. Therefore, tranzactional analysis is practical for us and easy to use for primary care. In Japan tranzactional analysis was introduced by Y. Ikemi and M. Sugita and developed as an important psychotherapy in psychosomatic medicine. After a therapeutist confirmed the motivation to care and stress evidence for patients, tranzactional analysis is adapted to psychosomatic disease as reaction for stress of their ordinary life. We showed the chronic respiratory failure patients of terminal stage to explain how to use tranzactional analysis practically.
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18.
論文(リポジトリ) |
田邊, 嘉也 ; 大矢, 聡 ; 塚田, 弘樹 ; 五十嵐, 謙一 ; 荒川, 正昭 ; 高野, 操 ; 尾崎, 京子
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19.
論文(リポジトリ) |
西, 慎一 ; 惠, 京仔 ; 小田, 瑞恵 ; 荒川, 正昭
概要:
The treatment of hypercholesterolemia was progressed rapidly with the appearance of new anti-hyperlipidemia agents, simvastain and plavastatin. These agents certainly decreased serum cholesterol level and ishemic events derived from
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atheloscrelosis of coronary artery. This results has been proved by several clinical mass studies. However, familial hypercholesterolemia(FH) is registive to statin agents and its pognosis is poor because of ishemic disease. Low density lipoprotein (LDL) apheresis is recognized as an effective treatment for lowering serum cholesterole level of FH patients. We studied our own FH treated with LDL apheresis and discussed the clinical effectiveness of LDL apheresis.
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20.
論文(リポジトリ) |
柄澤, 良 ; 鈴木, 芳樹 ; 笠井, 昭男 ; 阪田, 郁 ; 成田, 一衛 ; 荒川, 正昭
概要:
The number of diabetic patients suffering from end stage renal disease is increasing year by year. It is important to pr
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event and postpone the initiation and progression of diabetic nephropathy (DN). The purpose of this review is to discuss preventive treatment in the field of DN. The target of glycemic control is reported such as below 7.2 % and 6.5 % in serum HbA1c level in IDDM and NIDDM patients, respectively. Since it is difficult to achieve these targets, aldose reductase inhibitor, protein kinase C-β inhibitor and other drugs such as aminoguanidine may be a treatment which can compensate incomplete glycemic control. Concerning to glomerular hyperfiltration, ACE inhibitor (ACEI) is more beneficial among antihypertensive agents. Since recommended target level of blood pressure (BP) is below 130/85 mmHg (JNC VI), it is difficult to control BP using only ACEI, and then combination with other antihypertensive drugs will be necessary in many cases. The preventive effects of dietary protein restriction in the progeression of DN will be proven by prospective controlled multicenter-study. Administration of prostaglandin (PG) E1, PGI2, and pancreatic elastase (PE) induce the reduction of urinary albumin excretion rate (UAER) in some patients with DN. Long term effect of these agents remains to be investigated. Glycosaminoglycans (GAGs) including heparin is reported to reduce UAER in human and animal models of DN. GAGs with low anticoagulation action is necessary for clinical use. Concerning the clinical stage of DN, therapeutic approach to DN is summarized.
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21.
論文(リポジトリ) |
阪田, 郁 ; 赤岩, 靖久 ; 茂呂, 寛 ; 金子, 佳賢 ; 桑原, 克弘 ; 笠井, 昭男 ; 柄澤, 良 ; 木村, 秀樹 ; 鈴木, 芳樹 ; 荒川, 正昭 ; 桑原, 武夫 ; 田中, 恵子 ; 辻, 省次
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22.
論文(リポジトリ) |
笠井, 昭男 ; 鈴木, 芳樹 ; 柄澤, 良 ; 阪田, 郁 ; 荒川, 正昭
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23.
論文(リポジトリ) |
大森, さおり ; 小林, 茂 ; 横田, 樹也 ; 長谷川, 尚 ; 渡辺, 武 ; 黒田, 毅 ; 小沢, 哲夫 ; 中野, 正明 ; 荒川, 正昭
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24.
論文(リポジトリ) |
伊藤, 聡 ; 野沢, 悟 ; 小沢, 哲夫 ; 吉川, 哲哉 ; 星野, 賢一 ; 山崎, 秀 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 羽生, 忠正 ; 荒川, 正昭
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25.
論文(リポジトリ) |
米倉, 研史 ; 佐藤, 健比呂 ; 丸山, 雄一郎 ; 小林, 理 ; 村川, 英三 ; 東条, 猛 ; 林, 三樹夫 ; 江口, 功一 ; 上野, 光博 ; 鈴木, 享 ; 中野, 正明 ; 荒川, 正昭
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26.
論文(リポジトリ) |
伊藤, 聡 ; 渡辺, 武 ; 佐伯, 敬子 ; 上野, 光博 ; 佐藤, 浩和 ; 西, 慎一 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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27.
論文(リポジトリ) |
野沢, 悟 ; 伊藤, 聡 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村沢, 章 ; 鈴木, 栄一 ; 荒川, 正昭
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28.
論文(リポジトリ) |
成田, 一衛 ; 中川, 洋一 ; 上野, 光博 ; 西, 慎一 ; 鈴木, 亨 ; 荒川, 正昭
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29.
論文(リポジトリ) |
佐藤, 誠 ; 片桐, 敦子 ; 村松, 芳幸 ; 鈴木, 栄一 ; 荒川, 正昭
概要:
1) Chronic pulmonary disease (CPD) alters the mechanical and gas exchange properties of the respiratory system and impairs the patients' ability of physical activity and participation in the activities of daily life. Therefore,
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patients with advanced CPD who have achieved maximal benefit form conventional medical treatment and are still physically incapacitated are candidates for entry into a rehabilitation program. The assumption that both ventilatory muscle fatigue and ventilatory muscle weakness are important in limiting exercise performance in CPD patients has led to the use of various approaches to train ventilatory muscles specifically. 2) The goals of home health care are to minimize medical costs and improve patients' quality of life. Patients with CPD are especially vulnerable to emotional and physical restraints that can hamper quality of life. Home visiting nurses teach patients and their families to manage basic treatment regimes, including the proper use of medications and rehabilitation strategies.
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30.
論文(リポジトリ) |
市川, 健太郎 ; 張, 大全 ; 良田, 裕平 ; 若林, 昌哉 ; 吉沢, 弘久 ; 張, 高明 ; 荒川, 正昭 ; 橋本, 誠雄 ; 岸, 賢治
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31.
論文(リポジトリ) |
青池, 郁夫 ; 惠, 以盛 ; 下条, 文武 ; 荒川, 正昭 ; 林, 千治 ; 豊島, 英明 ; 小田, 瑞枝 ; 惠, 京仔
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32.
論文(リポジトリ) |
村松, 芳幸 ; 塚田, 智成 ; 真島, 一郎 ; 片桐, 敦子 ; 荒川, 正昭 ; 塚田, 浩治
概要:
So-called vegetative dystonia is a disorder characterized by patients’ complaint without organic changes. In this presen
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tation, 21 outpatients who were diagnosed to be functional symptomes at psychosomatic clinic were examined using psychological tests (Cornell Medical Index (CMI), Self Rating Questionaire for Depression (SRQ-D)). Grade 4 and 3 in Fukamachi's classification of CMI were considered to indicate neurosis and neurosis suspected neurosis. 76 % of these patients was diagnosed as neurosis or neurosis suspected, and 56 % as depressive state by using SRQ-D. Only one patient was diagnosed to be vegetative dystonia. From these results, so-called vegetative dystonia should be studied bio-psycho-social approaches.
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33.
論文(リポジトリ) |
黒田, 毅 ; 長谷川, 尚 ; 渡辺, 武 ; 岡田, 雅美 ; 中野, 正明 ; 荒川, 正昭
概要:
Osteoporosis is now recognized as one of the major problems of female SLE patients. We measured bone mineral density (BMD) in 54 female SLE patients using dual energy X-ray absorptiometory, and studied the relationship between BMD and
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clinical parameters or steroid and vitamine D treatment. There was an inverted relation between patient's age and BMD. BMD decreased remarkably in the age of forties and fifties. In the series study of BMD, both patients treated with vitamine D metabolites (group A) and those of untreated (group B) revealed no difference between initial and last BMD, The initial BMD of group A was significantly lower than that of group B. It means that vitamine D methabolites were administrated in patient showing lower DEXA. No remarkable difference were detected in serum biochemical parameters, creatinine clearance and urinary findings between two groups. BMD was not different between both nephrotic and non-nephrotic patients or between those with or without aseptic necrosis of femaral head. Further prospective controlled studies showed be performed to confirm the efficiency of vitamine D metabolites.
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34.
論文(リポジトリ) |
鈴木, 靖 ; 青池, 郁夫 ; 下条, 文武 ; 荒川, 正昭
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35.
論文(リポジトリ) |
金子, 晋 ; 目黒, 裕之 ; 鈴木, 芳樹 ; 上野, 光博 ; 柄沢, 良 ; 島田, 久基 ; 西, 慎一 ; 鈴木, 亨 ; 恵, 以盛 ; 木村, 秀樹 ; 成田, 一衛 ; 荒川, 正昭
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36.
論文(リポジトリ) |
岩本, 愛吉 ; 荒川, 正昭
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37.
論文(リポジトリ) |
荒川, 正昭
概要:
Sports medicine has been recognized to be an unique field of medicine, of which the subjects are not only the patients with bone, joint and muscle injuries or other organ disorders caused by sports activities but also the healthy young
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athletes who are training actively for making better records. Most of medical school graduates are not interested in sports medicine in Japan. However, the number of young doctors majoring in sports medicine are gradually increasing, although most of them are orthopedic surgeons. We are expecting that young physicians, pediatricians or psychiatrists will work up the interest in this field. In Niigata-ken Niigata Sports Medicine Society, which was build in 1984 as the only one research group of sports medicine in this area, has been promoting their research, particularly in the field of orthopedic surgery. In 1990 Niigata Amateur Sports Association organized a new committee, Sports Medecine Committee, which is non working for medical support of excellent young athletes or individual sports associations. There are 28 so-called "sports doctors" certified by Japan Amateur Sports Association in Niigata-ken, most of whom are participating as medical consultants in sports association. It is a good news that Niigata-ken has decided to build a new research institute of sports medicine in the near future. We hope that it will be useful to promote the research of sports medicine as well as to train promising young athletes.
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38.
論文(リポジトリ) |
長谷川, 尚 ; 椙谷, 博也 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 大澤, 治章 ; 岡, 一雅 ; 宮川, 芳一 ; 仲丸, 司 ; 大澤, 豊 ; 黒田, 毅 ; 柄澤, 良 ; 島田, 久基 ; 上野, 光博 ; 西, 慎一 ; 中野, 正明 ; 荒川, 正昭
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39.
論文(リポジトリ) |
佐藤, 英夫 ; 奥村, 弘史 ; 広瀬, 慎太郎 ; 大渕, 雄子 ; 黒田, 毅 ; 中野, 正明 ; 鈴木, 栄一 ; 荒川, 正昭
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40.
論文(リポジトリ) |
江村, 巌 ; 張, 高明 ; 柿原, 敏夫 ; 内藤, 眞 ; 若林, 昌哉 ; 吉沢, 弘久 ; 荒川, 正昭
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41.
論文(リポジトリ) |
青池, 郁夫 ; 荒川, 正昭
概要:
Hemodialysis is the most widely used mode of treatment for chronic renal failure (CRF) patients. Recent technological de
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velopments of devices and evolution of water purification procedure brought many advantages to the blood purification therapy. Especially, on-line preparation method for substitution fluid could remove massive exchangeable fluid by hemofiltration (HF) and hemodialfiltration (HDF). Furthermore, the direct blood perfusion device which can adsorb serum β2-microglobulin was developed. These treatments are quite possible to improve the prognosis of dialysis-related amyloidosis (DRA). New devices are used for the treatment of not only CRF but also acute renal failure (ARF) and/or multiple organ dysfunction Syndrome (MODS). Infectious disease and endotoxin shock are frequently seen in MODS. In these cases, endotoxin adsorption column which contains polymixine B is applied for treatment of endotoxicemia. This paper will present recent technical developments of CRF treatment and, in addition, acute blood purification for critically ill patients.
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42.
論文(リポジトリ) |
村上, 修一 ; 中野, 正明 ; 荒川, 正昭 ; 追手, 巍 ; 清水, 不二雄
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43.
論文(リポジトリ) |
菊地, 博 ; 佐藤, 健比呂 ; 丸山, 雄一郎 ; 村川, 英三 ; 島田, 久基 ; 上野, 光博 ; 荒川, 正昭
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44.
論文(リポジトリ) |
広瀬, 慎太郎 ; 塚田, 弘樹 ; 長谷川, 尚 ; 中野, 正明 ; 荒川, 正昭 ; 中村, 彰 ; 塙, 晴雄 ; 平松, 健 ; 粟森, 和明 ; 田中, 恵子 ; 和泉, 徹
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45.
論文(リポジトリ) |
小山, 裕子 ; 石塚, 康夫 ; 斎藤, 亮彦 ; 広瀬, 慎太郎 ; 長谷川, 尚 ; 中野, 正明 ; 鈴木, 栄一 ; 荒川, 正昭
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46.
論文(リポジトリ) |
黒田, 毅 ; 高橋, 章 ; 三束, 武司 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 中野, 正明 ; 荒川, 正昭
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47.
論文(リポジトリ) |
田中, 洋史 ; 大渕, 雄子 ; 広瀬, 慎太郎 ; 斉藤, 泰晴 ; 黒田, 毅 ; 中野, 正明 ; 荒川, 正昭 ; 藤原, 浩
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48.
論文(リポジトリ) |
宮川, 芳一 ; 成田, 一衛 ; 西, 慎一 ; 上野, 光博 ; 丸山, 弘樹 ; 中川, 洋一 ; 荒川, 正昭
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49.
論文(リポジトリ) |
丸山, 弘樹 ; 荒川, 正昭
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50.
論文(リポジトリ) |
筒井, 寿基 ; 斎藤, 和英 ; 片桐, 明善 ; 米山, 健志 ; 若月, 俊二 ; 水澤, 隆樹 ; 宮島, 憲生 ; 原, 昇 ; 星井, 達彦 ; 谷川, 俊貴 ; 武田, 正之 ; 高橋, 公太 ; 西, 慎一 ; 上野, 光博 ; 成田, 一衛 ; 島田, 久基 ; 荒川, 正昭 ; 甲田, 豊 ; 清水, 武昭 ; 平澤, 由平 ; 石川, 暢夫 ; 唐仁原, 全 ; 吉田, 和清
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51.
論文(リポジトリ) |
江村, 巌 ; 内藤, 眞 ; 柿原, 敏夫 ; 若林, 昌哉 ; 吉沢, 弘久 ; 荒川, 正昭 ; 石黒, 卓郎 ; 張, 高明 ; 林, 直樹
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52.
論文(リポジトリ) |
若林, 昌哉 ; 高橋, 正明 ; 田中, 純太 ; 田中, 洋史 ; 吉澤, 弘久 ; 鈴木, 栄一 ; 荒川, 正昭 ; 土屋, 俊晶 ; 丸山, 佳重
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53.
論文(リポジトリ) |
吉澤, 弘久 ; 田中, 洋史 ; 各務, 博 ; 田中, 純太 ; 若林, 昌哉 ; 鈴木, 栄一 ; 荒川, 正昭
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54.
論文(リポジトリ) |
青池, 郁夫 ; 荒川, 正昭
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55.
論文(リポジトリ) |
五十嵐, 謙一 ; 石塚, 康夫 ; 石塚, 修 ; 近, 幸吉 ; 塚田, 弘樹 ; 和田, 光一 ; 荒川, 正昭
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56.
論文(リポジトリ) |
山口, 義文 ; 新保, 俊光 ; 高橋, 正明 ; 若林, 昌哉 ; 吉澤, 弘久 ; 鈴木, 栄一 ; 荒川, 正昭
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57.
論文(リポジトリ) |
伊藤, 正洋 ; 鈴木, 芳樹 ; 轡田, 達也 ; 伊藤, 聡 ; 荒川, 正昭
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58.
論文(リポジトリ) |
伊藤, 聡 ; 野沢, 悟 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 羽生, 忠正 ; 荒川, 正昭
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59.
論文(リポジトリ) |
伊藤, 聡 ; 野沢, 悟 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 根本, 啓一 ; 荒川, 正昭
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60.
論文(リポジトリ) |
長谷川, 尚 ; 渡辺, 武 ; 黒田, 毅 ; 鈴木, 栄一 ; 中野, 正明 ; 荒川, 正昭
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61.
論文(リポジトリ) |
伊藤, 聡 ; 野沢, 悟 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 見田, 有作 ; 畑, 耕治郎 ; 斎藤, 徳子 ; 菊池, 正俊 ; 吉田, 和清 ; 荒川, 正昭
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62.
論文(リポジトリ) |
若杉, 三奈子 ; 黒田, 毅 ; 野沢, 悟 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 章 ; 上野, 光博 ; 西, 慎一 ; 鈴木, 亨 ; 荒川, 正昭
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63.
論文(リポジトリ) |
大森, さおり ; 黒田, 毅 ; 野沢, 悟 ; 石川, 肇 ; 遠山, 知香子 ; 中園, 清 ; 村澤, 彰 ; 中野, 正明 ; 荒川, 正昭
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64.
論文(リポジトリ) |
佐伯, 敬子 ; 長谷川, 尚 ; 渡邊, 武 ; 黒田, 毅 ; 伊藤, 聡 ; 上野, 光博 ; 西, 慎一 ; 中野, 正明 ; 荒川, 正昭
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65.
論文(リポジトリ) |
佐藤, 健比呂 ; 鈴木, 和夫 ; 大井, 秀美 ; 小林, 理 ; 丸山, 雄一郎 ; 阿部, 惇 ; 村川, 英三 ; 関谷, 政雄 ; 島田, 久基 ; 上野, 光博 ; 西, 慎一 ; 荒川, 正昭
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66.
論文(リポジトリ) |
石塚, 修 ; 塚田, 弘樹 ; 瀬賀, 弘行 ; 近, 幸吉 ; 五十嵐, 謙一 ; 和田, 光一 ; 荒川, 正昭
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67.
論文(リポジトリ) |
森山, 裕之 ; 伊藤, 和彦 ; 三間, 聡 ; 水沢, 章朗 ; 宮尾, 浩美 ; 若林, 昌哉 ; 吉沢, 弘久 ; 張, 高明 ; 鈴木, 栄一 ; 荒川, 正昭
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68.
論文(リポジトリ) |
川島, 崇 ; 塚田, 弘樹 ; 和田, 光一 ; 荒川, 正昭
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69.
論文(リポジトリ) |
小沢, 哲夫 ; 戸内, 英雄 ; 青木, 薫 ; 田中, 隆明 ; 高橋, 知香子 ; 中園, 清 ; 村沢, 章 ; 本間, 智子 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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70.
論文(リポジトリ) |
長谷川, 尚 ; 三浦, 義明 ; 横山, 靖 ; 上野, 光博 ; 高山, 龍 ; 鈴木, 亨 ; 柄沢, 良 ; 殷, 熙安 ; 西, 慎一 ; 荒川, 正昭
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71.
論文(リポジトリ) |
上野, 光博 ; 荒川, 正昭 ; 和泉, 貞次
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72.
論文(リポジトリ) |
佐藤, 匡 ; 丸山, 弘樹 ; 鈴木, 紀夫 ; 本間, 智子 ; 小澤, 哲夫 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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73.
論文(リポジトリ) |
本間, 智子 ; 堀, 知行 ; 和泉, 純子 ; 山田, 聡 ; 小沢, 哲夫 ; 佐藤, 健比呂 ; 鈴木, 栄一 ; 中野, 正明 ; 来生, 哲 ; 荒川, 正昭
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74.
論文(リポジトリ) |
菊池, 正俊 ; 青木, 薫 ; 関口, 秀隆 ; 吉田, 桂 ; 高橋, 知香子 ; 中園, 清 ; 村澤, 章 ; 小澤, 哲夫 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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75.
論文(リポジトリ) |
伊藤, 聡 ; 柄沢, 良 ; 上野, 光博 ; 鈴木, 芳樹 ; 下条, 文武 ; 荒川, 正昭 ; 佐藤, 一範 ; 傳田, 定平 ; 本多, 忠幸 ; 木村, 亮
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76.
論文(リポジトリ) |
鈴木, 紀夫 ; 川島, 崇 ; 和田, 光一 ; 荒川, 正昭
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77.
論文(リポジトリ) |
荒川, 正昭
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78.
論文(リポジトリ) |
荒川, 正昭
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79.
論文(リポジトリ) |
荒川, 正昭
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80.
論文(リポジトリ) |
佐藤, 健比呂 ; 捧, 博輝 ; 本間, 智子 ; 田辺, 肇 ; 小沢, 哲夫 ; 菊池, 正俊 ; 中野, 正明 ; 和田, 光一 ; 荒川, 正昭 ; 霜鳥, 孝
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81.
論文(リポジトリ) |
川島, 崇 ; 鈴木, 栄一 ; 和田, 光一 ; 来生, 哲 ; 荒川, 正昭
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82.
論文(リポジトリ) |
青柳, 竜治 ; 佐藤, 隆 ; 大原, 一彦 ; 下条, 文武 ; 荒川, 正昭 ; 高橋, 栄明
概要:
Parathyroidectomy (PTX) was performed in 8 hemodialysis patients (5 males, 3 females) with secondary hyperparathyroidism. All patients had received active vitamin D before PTX. The mean age of patients was 42.5 years and the mean
…
duration of hemodialysis period was 131.8 months. The average serum c-PTH was 31.0ng/ml before PTX. The removed parathyroid glands weighted from 1,100 to 3.570mg/patient (mean 2,365mg/patient). The bone specimen taken by transiliac biopsy was revealed the findings compatible with ostitis fibrosa. Bone pain, itching and vascular calcification of finger vessel were reduced after PTX. Subperiosteal bone resorption disappeared in 6 patients.
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83.
論文(リポジトリ) |
林, 直樹 ; 荒川, 正昭
概要:
The treatment of adult acute lymphocytic leukemia (ALL) has been still unsatisfactory because of high relapsing rate aft
…
er complete remission (CR) and easy acquirement of multiple drug resistance, although that of childhood ALL has been improved remarkably. In order to keep long-term CR, more intensive induction, consolidation and maintenance therapies have to be introduced. Based on this therapeutic concept, Memorial Sloan Kettering's group has introduced L-series protocol and reported favorable clinical results. We have tried modified L-10M protocol as our standard regimen since 1985. All 5 patients treated so far have achieved CR, but relapse in central nerve system (CNS) was found in 2 cases after cessation of intrathecal methotrexate injection, which suggested the importance of prophylactic treatment for CNS leukemia. In addition to the progress of chemotherapeutic strategy, the development of diagnostic methods, more advanced supportive therapies and bone marrow transplantation shoud be considered for improving clinical results. Finally, attempts for developing new chemotherapeutic agents, new treatment programs and novel immunotherapy (application of biological response modifiers etc) will be necessary for getting better clinical results in adult ALL.
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84.
論文(リポジトリ) |
二宮, 裕 ; 鈴木, 丈吉 ; 荒川, 正昭
概要:
Because of the varied types and manifestations of diabetes mellitus, the effects of dietary treatment and physical train
…
ing as regarding control of hyperglycemia were varied. We evaluated the effects of dietary treatment and physical training after 4weeks' admission relative to an index of percent desirable weight (PDW) and fasting blood sugar (FBS) level prior to the admission, and also evaluated how to be treated one year afterwards. Mass screening for chronic diseases in adults was performed in Nagaoka, Niigata Prefecture in 1985. The 75g oral glucose tolerance test was examined for all the glucosuria positive cases and 159 cases as diabetic type were evaluated. 159 cases were classified according to PDW as follows; group 1; 80<PDW<100, group 2; 100<PDW<120 and group 3; 120<PDWく140. Each group was subclassified according to FBS; group A; FBSく200, and group B; FBS<200. All the cases had no medication for hyperglycemia during 4 weeks' admission. Decreased FBS after 4 weeks' admission correlated with PDW measured before admission, while there was no correlation between FBS and PDW before admission. After one year, percentage of patients who required insulin therapy was the following ; group 1; 50%, group 2; 6% and group 3; 6%. In conclusion, the control of hyperglycemia by dietary treatment and physical training without using any hypoglycemic agent was difncult in patients who had high FBS and /or low PDW when first diagnosed as diabetes mellitus.
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85.
論文(リポジトリ) |
下条, 文武 ; 中野, 正明 ; 荒川, 正昭
概要:
Membrane plasmapheresis is a new therapeutic tool to control patients with autoimmune and metabolic disorders. Double filtration plasmapheresis, in which two membrane filters with different pore size are utilized to selectively remove
…
pathogenic macromolecules in plasma, has been found to be safe and efficient system of membrane plasmapheresis for various autoimmune diseases. In Niigata University Hospital, 30 patients with autoimmune and hyperlipidemic diseases have been treated with double filtration plasmapheresis and 21 patients with metabolic diseases have been done with single membrane plasma exchange using fresh-frozen plasma. We have observed no major side effects in this treatment. Plasmapheresis presently is an appropriate symptomatic treatment, and future research must undertake to clarify the pathogenic factors which should be removed from the blood.
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86.
論文(リポジトリ) |
和田, 光一 ; 荒川, 正昭
概要:
114 cases of bacteremia through 1976 to 1985 at our department were studied. 128 strains were isolated from blood cultur
…
e, 23 of Staphylococcus aureus, 7 of α-streptococcus, 4 of Enterococcus faecalis, 13 of Escherichia coli, 9 of Klebsiella pneumoniae, 20 of Pseudomonas aeruginosa, 11 of non-fermentative gram negative rod(NFGNR), 9 of yeast like fungi and 32 of others. Bacteremia increased in these five years, particulary caused by S.aureus, P.aeruginosa, NFGNR and yeast like fungi. These strains were frequently isolated from catheter tip. These findings suggest that insertions of catheters were cause of bacteremia increase. The prognosis of bacteremia due to P.aeruginosa was poor, and with leucopenia, the prognosis was poor, too.
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87.
論文(リポジトリ) |
菊池, 正俊 ; 小沢, 哲夫 ; 佐藤, 健比呂 ; 長尾, 政之助 ; 荒川, 正昭 ; 中野, 正明
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88.
論文(リポジトリ) |
田崎, 和之 ; 和田, 光一 ; 下条, 文武 ; 荒川, 正昭
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89.
論文(リポジトリ) |
庭山, 昌俊 ; 伊藤, 聡 ; 田崎, 和之 ; 五十嵐, 謙一 ; 長尾, 政之助 ; 森本, 隆夫 ; 和田, 光一 ; 林, 直樹 ; 荒川, 正昭
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90.
論文(リポジトリ) |
和田, 光一 ; 田崎, 和之 ; 五十嵐, 謙一 ; 森本, 隆夫 ; 庭山, 昌俊 ; 荒川, 正昭 ; 尾崎, 京子 ; 高野, 操 ; 小柳, 典子 ; 狩野, 倫佳
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91.
論文(リポジトリ) |
星野, 重幸 ; 河本, 広志 ; 来生, 哲 ; 荒川, 正昭
概要:
We investigated the bronchial hyperresponsiveness to methacholine chloride by Astograph in patients with bronchial asthm
…
a, chronic obstructive lung disease, sarcoidosis and interstitial pneumonia. The results were as follows. 1)Bronchial sensitivity (Dmin) was highest in patients with bronchial asthma and significant difference was observed between patients with bronchial asthma and normal subjects (p<0.001). This suggests that bronchial sensitivity can be well assessed by Astograph. Significant differences were also observed between normal subjects and patients with COLD, sarcoidosis and interstitial pneumonia. 2)No significant difference in Dmin was observed between patients with atopic asthma and nonatopic asthma. 3)Dmin was significantly higher in patients with moderate asthma than in those with mild asthma. 4)Significant correlations were observed between Grs c and Dmin (p<0.001) and between Grs c and SGrs (p<0.05) in patients with bronchial asthma, but no significant correlations were observed between Dmin and SGrs or SGrs/Grs c.
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92.
論文(リポジトリ) |
上野, 光博 ; 荒川, 正昭
概要:
Intrarenal vascular lesions of diabetic glomerulosclerosis were evaluated in order to clarify the relationship between vascular lesions and diabetic nephropathy in 108 NIDDM patients. Index of arteriolar hyalinous change (IAHC),
…
designed as grade of AHC, was correlated significantly with age at biopsy, DM duration, GFR, PSP (15'), urine protein, systolic blood pressure (BP) and index of glomerular lesion (IGL). IAHC was also higher in hypertensive patients than in normotensive patients. Intimal thickening of small arteries (IT/SA) had a significant correlation with DM duration, systolic BP, GFR and Fishberg's concentration test. IAHC and IGL were significantly higher in IT/SA (+) group than in IT/SA (-) group. Intimal thickening of arteries (IT/A) was not related with clinical findings, although IAHC was significantly higher in IT/A (+) group. In conclusion, arteriolar hyalinosis may be closely related to the progression of diabetic nephropathy and intimal thickening of small arteries and arteries may contribute as well.
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93.
論文(リポジトリ) |
岡田, 雅美 ; 柳, 雅彦 ; 恵, 以盛 ; 柄沢, 良 ; 殷, 煕安 ; 佐藤, 浩和 ; 西, 慎一 ; 上野, 光博 ; 鈴木, 芳樹 ; 荒川, 正昭
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94.
論文(リポジトリ) |
中島, 喜章 ; 畠山, 忍 ; 鈴木, 栄一 ; 永井, 明彦 ; 来生, 哲 ; 荒川, 正昭 ; 俵谷, 幸蔵 ; 原口, 通比古
概要:
Twenty patients with small cell lung cancer (SCLC), 11 limited disease (LD) and 9 had extensive disease (ED), were treat
…
ed with a combination chemotherapy consisting of ADM (40mg/m^2, i.v., day 1), VCR (1mg/m^2, i.v., day 1), ETP (60mg/m^2, i.v., day 1~5) and CPA (600mg/m^2, i.v., day 1) (AVEC therapy) at 4week intervals. The overall response rate and the complete response (CR) rate were 100% (11/11) and 36% (4/11) in LD cases, and 78% (7/9) and 0% (0/9) in ED cases, respectively. The median response duration were 9 months in LD cases and 2 months in ED cases. The median survival time of LD, ED and all cases were 13, 9 and 13 months, respectively. The over 3 years survival rate was 20% (4/20). The major toxicity was myelosupression, although it was well tolerated. These results suggest that the AVEC therapy is effective for SCLC.
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95.
論文(リポジトリ) |
伊藤, 聡 ; 石塚, 修 ; 本間, 智子 ; 島田, 久基 ; 上野, 光博 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭 ; 本間, 篤 ; 小池, 亮子 ; 川崎, 朋美 ; 大沢, 薫子 ; 風間, 隆 ; 石川, 裕之 ; 渡辺, 英伸 ; 桧前, 薫 ; 生田, 房弘
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96.
論文(リポジトリ) |
小沢, 哲夫 ; 山崎, 秀 ; 石川, 肇 ; 中園, 清 ; 村澤, 章 ; 本間, 智子 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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97.
論文(リポジトリ) |
佐伯, 敬子 ; 渡辺, 武 ; 伊藤, 聡 ; 上野, 光博 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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98.
論文(リポジトリ) |
野沢, 悟 ; 小澤, 哲夫 ; 星野, 賢一 ; 山崎, 秀 ; 石川, 肇 ; 中園, 清 ; 村澤, 章 ; 鈴木, 栄一 ; 荒川, 正昭
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99.
論文(リポジトリ) |
和田, 光一 ; 瀬賀, 弘行 ; 荒川, 正昭
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100.
論文(リポジトリ) |
中村, 享道 ; 荒川, 正昭 ; 追手, 巍 ; 清水, 不二雄
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