3) 薬剤性肝障害(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)

フォーマット:

論文(リポジトリ)

責任表示:

石原, 清 ; 太田, 宏信 ; 吉田, 俊明 ; 市田, 文弘

出版情報:

新潟医学会, 1986-09

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

• 石原, 清
• 太田, 宏信
• 吉田, 俊明
• 市田, 文弘

巻:

100

通号:

9

開始ページ:

501

終了ページ:

505

概要:

Clinical and histological features, treatment and prognosis were studied in 206 patients who met the criteria of drug-induced hepatic injury. The results were as follows: Of all causative drugs, cardiovascular agents were the most frequent, followed by CNS acting drugs secondly and antibiotics thirdly The following lndividual drugs was arranged in order of frequency: ajmalin, halothane, cefems, and methyldopa. Characteristic clinical and histological … findings were observed in each drugs. They could be generally divided into two groups of intrahepatic cholestasis and hepatocellular damage. The clinical course of the former type tended to be prolonged, and steroid was not effective to this type. In nine cases, the duration of illness was more than six months.The disturbance of consciousness was observed in 10 cases and eight patients in these were dead due to hepatic coma, acute renal failure, or gastrointestinal bleeding. 続きを見る

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