1) 全身性エリテマトーデスにおける自己抗体の臨床意義 : とくに抗DNA抗体と抗リン脂質抗体について(シンポジウム 自己免疫疾患, 第445回新潟医学会)
- フォーマット:
- 論文(リポジトリ)
- 責任表示:
- 菊池, 正俊 ; 小澤, 哲夫 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
- 出版情報:
- 新潟医学会, 1989-12
- 掲載情報:
- 新潟医学会雑誌 — 新潟医学会雑誌
- ISSN:
- 00290440
- 著者名:
- 巻:
- 103
- 通号:
- 12
- 開始ページ:
- 961
- 終了ページ:
- 967
- 概要:
- Systemic lupus erythematosus (SLE) is characterized by production of many autoantibodies. The clinical significance of the autoantibodies, especially anti-DNA antibody and antiphospholipid antibodies, was discussed in this paper. Anti-dsDNA antibody is highly specific for SLE and rarely seen in a significant titer in other rheumatic diseases. This antibody is useful for assessing desease activity. It can bind to several cellular components or bacterial … polysaccharides, which suggest that the restricted anti-DNA antibody may account for the serological abnormalities and the tissue injury in SLE. Anti-phospholipid antibodies include BFP-STS, lupus anticoagulant, anti-cardiolipin antibody and anti-phosphatidyl serine antibody. These antibodies had a significant correlation with fetal wastage, thrombocytopenia, CNS lupus and thrombosis. We observed 3 patients who had successful pregnancies after anti-phosphatidyl serine antibody reduced to normal level. Anti-phpsphatidyl serine antibody is surely useful for the management of pregnancy in lupus patients. 続きを見る
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