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論文(リポジトリ)

論文(リポジトリ)
佐藤, 勇
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  102  pp.112-120,  1988-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/40623
概要: The changes in tumor volume after radio-chemotherapy were studied in 48 patients with anaplastic glioma (glioblastoma) b y repeated contrast enhanced (CE) computed tomography (CT). The tumor volume was determined by calculating the area of the CE lesion measured at three dimension on CT slices. The patients could be classified into 3 groups according to the type of the changes in tumor volume after the therapy. Group 1: 8 patients (17%) had tumors showing a progressive increase in tumor volume after the completion of the therapy. Group 2: 23 patients (48%) had tumors which were almost stable for 5.6±2.7 months after the therapy. Group 3: 17 patients (35%) had tumors showing more than -30% reduction in volume after the therapy. Maximum reduction of 68±17% was observed 6.4±3.2 months after the therapy. These tumors showed regrowth 11.7±4.3 months after the therapy. In 11 patients (48%) of Group 2 and in 6 (35%) of Group 3, the volume of the CE lesion increased transiently by +3 to +36% 1.5±1.1 months after the therapy. In 14 (82%) of these 17 patients, peri-focal low density was extended around the CE lesion, But these changes showed improvement within 2 months. These earl changes were considered to be transient reactions to the radio-chemotherapy. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
佐藤, 勇
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  102  pp.121-130,  1988-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/40631
概要: The patterns of tumor growth and extension after the recurrence were studied in 48 patients with cerebral anaplastic gli omas (glioblastomas) by computed tomography(CT). All these patients were treated with surgical extirpation and radio-chemotherapy as the induction therapy, and followed by CT at average intervals of 1.0±0.6 months. In this study, only CE lesion was estimated as tumor. These 48 patients were divided into subcortical group (34 cases) and deep seated group (14 cases) by the initial location of CE lesion before treatment. The patterns of tumor growth and extension could be classified into four groups: a) extension to subcortical white matter (38 cases: 79%), b) extension along periventricles (40 cases: 83%) , c) extension towards basal ganglia (21 cases: 44%), d) remote metastasis via cerebrospinal fluid to the brain surface and posterior fossa (10 cases: 21%). The patients showed one or more of these patterns during the follow-up. In the subcortical group, CE lesions extended step-wise to the ipsilateral periventricular region, corpus callosum, contralateral periventricle and to the whole ventricles, at 0.5±3.1, 2.7±3.1, 4.0±3.8 and 6.1±2.9 months after the recurrence, respectively, and after the subsequent 1.8±2.0 months, the patients finally died. Similar step-wise growth patterns wore observed also in the deep-seated group, but the location of tumor was so various that it was not as easy as in the subcortical group to predict the prognosis of the patients. 続きを見る