close
1.

論文(リポジトリ)

論文(リポジトリ)
菊池, 正俊 ; 小澤, 哲夫 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  103  pp.961-967,  1989-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/41471
概要: Systemic lupus erythematosus (SLE) is characterized by production of many autoantibodies. The clinical significance of the autoantibodies, especially anti-DNA antibody and antiphospholipid antibodies, was discussed in this paper. Anti-dsDNA antibody is highly specific for SLE and rarely seen in a significant titer in other rheumatic diseases. This antibody is useful for assessing desease activity. It can bind to several cellular components or bacterial polysaccharides, which suggest that the restricted anti-DNA antibody may account for the serological abnormalities and the tissue injury in SLE. Anti-phospholipid antibodies include BFP-STS, lupus anticoagulant, anti-cardiolipin antibody and anti-phosphatidyl serine antibody. These antibodies had a significant correlation with fetal wastage, thrombocytopenia, CNS lupus and thrombosis. We observed 3 patients who had successful pregnancies after anti-phosphatidyl serine antibody reduced to normal level. Anti-phpsphatidyl serine antibody is surely useful for the management of pregnancy in lupus patients. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
佐藤, 健比呂 ; 内海, 利男 ; 木南, 凌 ; 荒川, 正昭
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  108  pp.194-199,  1994-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38109
概要: We examined sera from 90 active patients with systemic lupus erythematosus (SLE) for the presence of anti-ribosomal protein antibodies by Western-blotting, and also tested these sera for reactivity with ribosomal RNA (rRNA) by RNase T1 protection assay. Anti-P, anti-S10 and anti-L12 protein antibodies were detected in 38 (42%), 28 (31%) and 2 (2%) patients' sera, respectively. The anti-RNA antibody specific for the GTPase domain of 28S rRNA (anti-28S) was present in 15 (17%) sera. Cutaneous manifestations were dominant in anti-P, anti-S10 as well as anti-28S positive patients. Among 38 anti-P positive patients 3 developed acute lupus psychosis, and another 5 showed depression during their course of disease. These observations suggest that anti-ribosomal antibodies provide a useful marker for this disease. All anti-28S positive sera also contained anti-P activitiy and two of them have anti-L12 as well. There is no difference of anti-S10 frequency between anti-P positive sera and negative ones. It is therefore likely that strong association of three anti-ribosomal antibodies to the P proteins, L12 and GTPase domain of 28S RNA is due to an immune response against the limited RNA-protein complex domain in the ribodsome. 続きを見る