大腸腫瘍におけるCEAの免疫組織学的研究 : 良性と悪性の腫瘍を鑑別するための有用性について
- フォーマット:
- 論文(リポジトリ)
- 責任表示:
- 須田, 武保 ; 岩渕, 三哉 ; 渡辺, 英伸 ; 岡本, 春彦 ; 鹿嶋, 雄治 ; 山井, 健介 ; 下田, 聡 ; 井上, 雄一朗 ; 工藤, 進英 ; 畠山, 勝義 ; 小山, 真 ; 武藤, 輝一
- 出版情報:
- 新潟医学会, 1986-06
- 掲載情報:
- 新潟医学会雑誌 — 新潟医学会雑誌
- ISSN:
- 00290440
- 著者名:
須田, 武保 岩渕, 三哉 渡辺, 英伸 岡本, 春彦 鹿嶋, 雄治 山井, 健介 下田, 聡 井上, 雄一朗 工藤, 進英 畠山, 勝義 小山, 真 武藤, 輝一 - 巻:
- 100
- 通号:
- 6
- 開始ページ:
- 357
- 終了ページ:
- 365
- 概要:
- Localization of cellular and tissue carcinoembryonic antigen (CEA) was studied for the colorectal tumor by immunoperoxidase technique using monoclonal antibody against CEA (CM-010), and this specific localization was examined whether useful or not in differential diagnosis of the colorectal tumor. Twelve hyperplastic polyps, 107 adenomas, 188 carcinomas and 6 anticancer drug-induced colitis in formalin-fixed and paraffin-embedded specimens obtained by surgical operation … and polypectomy were studied. The positive CEA staining was classified according to its localization in the cells as follows; Grade 1: CEA was positive only along the apical surface of the cells, Grade 3 : CEA was positive along the apical surface and basolateral cell membrane as well as in the cytoplasm and intraglandular material, Grade 2 : CEA was localized intermediately between Grade 1and Grade 3. The positive ratio and Grade 3 frequency of CEA were demonstrated respectively as follows; hyperplastic polyps 58.3% and 8.3%, adenomas 71.0% and 11.2%, and carcinomas 91.5% and 77.1%. Thease findings suggested Grade 3 localization of CEA was high frequency for the carcinoma and useful in differential diagnosis of the malignancy from the benign colorectal tumor. 続きを見る
- E-Resources:
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