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1.

論文(リポジトリ)

論文(リポジトリ)
斎藤, 眞理 ; 清野, 康夫 ; 植松, 孝悦 ; 栗田, 雄三 ; 横山, 晶
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  109  pp.332-337,  1995-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/42515
概要: In comparison with operation, we observed more recurrence after external beam radiotherapy for roentogenographically occ ult lung cancer. Then, since July 1991, we have treated that lung cancer, with external beam radiotherapy and intraluminal afterloading irradiation using ^<192>Iridium thin wire. The indication of this method is roentogenographically occult lung cancer, diagnosed inoperable for their respiratory function, age, and complications, and for refusal of operation. Up to Sept. 1994, 36 patients (44 lesions) were treated by this method. The follow-up period ranged from 0 to 41 months. Recurrence occured in 2 cases on whom an operation was done:one is well and the other is alive with disease. Radiation pneumonitis required treatment was observed in another 2 cases. Other recurrence or severe complications from irradiation have not been observed. We think this treatment is effective for roentogenographically occult lung cancer. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
西山, 健一 ; 吉村, 淳一 ; 藤井, 幸彦
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  126  pp.71-75,  2012-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/31404
概要: Clinical outcome of treatment for 64 patents with medulloblastoma were analyzed and our current strategies with historical comparisons were discussed. From 1992 to present, 25 patients were treated with our current regimen with maximum resection, receiving 36Gy of cerebrospinal irradiation (CSI) with a posterior fossa boost of 18-24Gy starting within two weeks after surgery. The 5-year overall survival was 79.2%. This is relatively high, however the late radiation injury of cognitive dysfunctions and endocrinological sequelae were observed in younger children. We consider that reducing the dose of CSI to 24Gy with induction of adjuvant chemotherapy in average-risk patients is considered to be appropriate for preventing late radiation injury and improving the survival rate. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
青山, 英史
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  125  pp.463-468,  2011-09.  新潟医学会
本文リンク: http://hdl.handle.net/10191/29270
概要: 新潟大学病院において高精度放射線治療装置の本格的稼働が開始となった. 本システムは優れた画像誘導機能が搭載されており, 非観血的に1mm未満の物理精度を担保した定位照射を行うことが可能である. 聴神経鞘腫への定位照射の有効性は既に広く認識さ れているが, 我々の検討により腫瘍径1-2cm以下かつ有効聴力が保たれた状態で治療した場合, 99%の腫瘍制御率と5-7割の症例で有効聴力温存が可能であることが示された. 今後, 当県においても, 様々な疾患で有害反応が少ない高精度の放射線治療が展開されるであろう. 続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
稲越, 英機
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.169-174,  1990-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/33733
概要: Radiation therapy is an important treatment modality in the management of breast cancer patients. In 1970's, postoperative radiotherapy was claimed that it had increased the incidence of distant metastasis in early breast cancer. However, the dose and field of postoperative radiotherapy in the trials referred had been regarded as outdated in that era. As an adjuvant therapy, radiotherapy establishes control of subclinical diseases in the regional lymphnodes and may decrease the incidence of distant metastasis in high risk patients. As a conservative treatment modality, radiotherapy achieves locoregional control of 90% in early breast cancer. Also in selected bulky diseases, boosting interstitial temporary implants, such as iridium-192 seed assembly or wire, yield fair locoregional control and good aesthetic results. 続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
笹本, 龍太
出版情報: 新潟大学保健学雑誌 = 新潟大学保健学雑誌.  15  pp.57-65,  2018-03.  新潟大学医学部保健学科
本文リンク: http://hdl.handle.net/10191/49819
概要: 放射線治療計画における計画標的体積(PTV)は,照射位置のばらつきによる等線量曲線の偏位を補償するための余白(PTVマージン)を,腫瘍細胞の存在範囲に加えることで作成する.今回,必要なPTVマージンの値に照射野の形状が及ぼす影響を検討するこ とを目的に,van Herkの理論値(正確法,近似法)の妥当性を検討した.部分的に凸形~凹形を有する7種類の照射野を作成し,照射方向は対向2門,4 MV X線と10 MV X線でそれぞれ線量分布を計算した.線量分布にばらつきを加える数値シミュレーションを行い,等線量曲線(処方線量の95%)の偏位を理論値と比較した.正確法は照射野辺縁が平坦な場合はシミュレーションと一致したが,照射野の凹凸が大きくなると不一致が見られた.近似法は多くの場合不一致が見られたが,不一致の範囲は正確法より小さかった.PTVマージンの算出に際しては,照射野形状の考慮が必要である.<br />The planning target volume (PTV) on the radiotherapy plan is created by adding a margin (PTV margin) to the volume in which tumor cells spread, for compensating the deviation of the isodose curve due to geometrical uncertainties. In this study, the validity of van Herk's theoretical value (precise method, approximation method) was evaluated for the purpose of examining the impact of the irradiation field shape on necessary PTV margin value. Seven types of irradiation fields with partially convex to concave shapes were prepared, and the dose distributions were calculated with the parallel opposed fields, using 4 MV X-ray and 10 MV X-ray data. Numerical simulation was carried out to add geometrical uncertainties to the dose distribution, and the deviation of the isodose line (95% of the prescribed dose) was compared with the theoretical value. The precise method was consistent with the simulation when the edge of the irradiated field was flat, but inconsistency was observed when the irregularities of the irradiation field was increased. Although the approximation method was found to be inconsistent in many cases, the range of inconsistency was smaller than that of the precise method. When calculating the PTV margin, the influence of the irradiation field shape should be taken into account. 続きを見る
6.

論文(リポジトリ)

論文(リポジトリ)
笹本, 龍太 ; 宇都宮, 悟 ; 早川, 岳英
出版情報: 新潟大学保健学雑誌 = 新潟大学保健学雑誌.  14  pp.9-15,  2017-03.  新潟大学医学部保健学科
本文リンク: http://hdl.handle.net/10191/47192
概要: 放射線治療の呼吸同期照射において,同期信号の発生からビームオン・オフまでには遅延時間(time\ndelay)がある.今回,time delayの計測に適した動体ファントムの運動パターンと,新潟大学医歯学総合病院の呼吸同期照射システムにおけ るtime delayを明らかにすることを目的として検討を行った.動体ファントムの運動波形はサイン波形と等速波形とし,運動幅は30 mmとした.ラジオクロミックフィルムを動体ファントムに乗せ,直径4 mm coneで連続照射を行ったところ,フィルム上の照射陰影はサイン波形で31.7±0.2mm,等速波形で30.4±0.1 mmであり,等速波形の方が実際の運動幅に近く,測定精度が高かった.次に等速波形を用いた10-40%位相の同期照射を行い,照射陰影の長さを理論値と比較したところ,time delayはビームオンで0.11±0.01秒,ビームオフで0.07±0.00秒であった.<br />In respiratory gated radiotherapy, there are time delays between the target entering the gated region and treatment beam on, and between the target exiting the gated region and treatment beam off. The aim of this study was to clarify the appropriate motion profile of motion phantom for measuring the time delays, and to measure the beam on and beam off time delays in respiratory gated radiotherapy system at Niigata University Medical and Dental Hospital. We irradiated radiochromic films on the motion phantom using 4 mm diameter cone without gating. As a motion profile for the motion phantom (motion width: 30.0 mm), a sinusoidal profile and a constant velocity profile ware used. Measured length of the exposure streaks on the films were more accurate with the constant velocity profile than those with the sinusoidal profile (30.4±0.1 mm vs. 31.7±0.2 mm). Then we used the constant velocity profile for gating irradiation with a gating phase range of 10-40%, and compared the exposure streak length with a theoretical value. The calculated beam on time delay was 0.11±0.01 sec, and the beam off time delay was 0.07±0.00 sec. 続きを見る
7.

論文(リポジトリ)

論文(リポジトリ)
生越, 章
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  120  pp.243-248,  2006-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/5272
概要: Multimodality approach for the diagnoses and treatments for malignant tumors has improved the survival and quality of life. The principles of treatment of osteosarcoma have undergone dramatic changes in past 40 years. Until 1960's, five-year survival was less than 10%. The advancement of chemotherapy has improved the prognosis, and 70% of the patients can be expected to be long-term survivors. Conservative surgery combined with radio-chemotherapy has improved not only the prognosis but also the function of affected limbs. Teamwork of well-trained medical stuff is extremely important for the treatment of malignant tumors. 続きを見る
8.

論文(リポジトリ)

論文(リポジトリ)
荻野, 尚
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  121  pp.11-15,  2007-01.  新潟医学会
本文リンク: http://hdl.handle.net/10191/20129
概要: Proton beam therapy (PBT) makes it possible to deliver a higher concentration of radiation to the tumor by its Bragg-peak, and is easy to utilize by its identical biological characteristics with X-rays. PBT has a half-century history, and more than 40,000 patients have been reported as having had treatments with proton beams worldwide. The historic change to this therapy occurred in the 1990s, when the Loma Linda University Medical Center began its clinical activity as the first hospital in the world to utilize medically dedicated proton therapy facility. Since then, similar hospital-based medically dedicated facilities have been constructed. Results from around the world have shown the therapeutic superiority of PBT over alternative treatment options for ocular melanoma, skull base sarcoma, head & neck cancer, lung cancer, esophageal cancer, hepatocellular carcinoma, and prostate cancer. PBT is expected to achieve advancement both clinically and technologically. 続きを見る