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論文(リポジトリ) |
論文(リポジトリ)
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斎藤, 俊弘 ; 片桐, 明善 ; 冨田, 善彦
概要:
Metastatic renal cell cancer (RCC) is usually treated with immunotherapy using cytokines because it is a mostly chemores
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istant malignancy. These therapies are generally based on interleukin-2 (IL-2) or interferon. However, their response rates were less than 20% and various side effects appeared. In order to improve response rate or reduce side effects, we have tried LAK (lymphokine-activated killer cells) therapy and low dose interferon γ therapy. LAK cells are peripheral blood lymphocytes activated in vitro by exposure to IL-2. LAK therapy was done 10 course for 9 patients in our hospital and the overall respones rate was 60%. On the other hand, low dose interferon γ therapy was done for 10 patients and the side effects were relatively small with the response rate of 10%. These results indicate that immunotherapy using cytokines are useful for metastatic renal cancer and its strategy, including dosage, combination therapy, is still to be investigated.
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| 2.
論文(リポジトリ) |
論文(リポジトリ)
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SUDA, Takeshi ; OHKOSHI, Shogo ; AOYAGI, Yutaka ; FUJIMAKI, Takashi ; NARISAWA, Rintaro ; NOMOTO, Minoru ; KAMIMURA, Tomoteru ; TANAKA, Kenichi ; ASAKURA, Hitoshi
概要:
We report here a case of a 21-year-old Japanese woman suffering from severe acute liver injury due to hepatitis C virus (HCV) infection in the third trimester of her first pregnancy. When a second-generation antibody reactivity
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to HCV had not yet appeared, HCV RNA was detected in her serum using a polymerase chain reaction. Subsequent natural interferon-alpha therapy played a key role in the recovery from severe hepatic injury, and the disappearance of HCV RNA in her serum. Consequently, HCV RNA has not been detected for over 17 months after the cessation of interferon administration. On the other hand HCV RNA was not detected in her cord or the baby serum. Therefore, maternal transmission of HCV was not evidenced. This is a rare case in which a severe form of acute hepatitis C was successfully treated with natural interferon-alpha, and no indication of a maternal transmission of HCV in acute hepatitis C could be demonstrated with polymerase chain reaction analysis.
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