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1.

論文(リポジトリ)

論文(リポジトリ)
兼子, 泰行
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  105  pp.177-186,  1991-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38651
概要: To investigate alterations in the basement membrane (BM) and of fibronectin receptor (FNR) in malignant melanoma (MM), t he tumor were studied immunohistochemically by double immunofluorescent staining using monoclonal antibodies to the core protein of heparan sulfate proteoglycan(HSPG), collagen type III(C-3)and chondroitin 6-sulfate (C6S) as well as antiserum to laminin, collagen type IV (C-4), fibronectin and fibronectin receptor. In MM in situ, C-4, laminin and HSPG were preserved as a continuous linear band on the dermo-epidermal junction (DEJ), while C6S is extensively lost from the DEJ and fibronectin is remarkably decreased in the papillary dermis compared with the normal skin. In invasive, MM, although the distribution pattern was varied case by case, the BM components were not decreased. The cases were divided into two groups by the distribution pattern; a great amount of each BM component were localized on the surface of tumor cells, or surrounded tumor nests, forming the large nests. In all but one cases examined, however, C6S was absent from the BM zone of the melanoma nests in the dermis. These data indicates that although C6S was absent, the other BM components were actively synthesized by tumor cells, and that the BM components were altered in phase of MM in situ. Intensity of FNR of melanoma cells were generally more fainter than those of infiltrating lymphocytes in the dermis, basal cells of the epidermis and endothelial cells of small vessels. There were no significant differences in their intensity of melanoma cells between each tumor progression phase. Therefore, the present study may reveal that these receptors do not relate to invasion or metastasis of the tumor. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
桧森, 昌門
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  102  pp.365-371,  1988-06.  新潟医学会
本文リンク: http://hdl.handle.net/10191/40793
概要: Fibrotic process in liver diseases is based on the quantitative changes of extracellular matrix components. In this study, the localization of proteodermatan sulfate (PDs) was investigated in 55 cases with various liver diseases. Polyclonal antibodies to the core protein of PDs isolated and purified from human placenta, fibronectin, laminin and type III collagen were used for this purpose. Results indicated that PDs was mainly localized at the matured fibrotic areas rather than the areas of liver cell necrosis or of inflammatory cell infiltration where new fibrogenesis was predicted. These data suggest that PDs has more close interrelationship with matured collagen fibers (type I collagen) in contrast to fibronectin or type III collagen and that PDs plays an important role in the conservation of hepatic fibrosis rather than in new fibrogenesis. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
村瀬, 真一
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  123  pp.1-8,  2009-01.  新潟医学会
本文リンク: http://hdl.handle.net/10191/28226
概要: ヒトをはじめ哺乳類の脳には, その発達期だけでなく生涯を通じて側脳室周囲から嗅球へ向かいニューロブラスト (神経前駆細胞) が一方向性に移動する経路があり rostral migratorystream (HMS) と呼ばれている. RMS は, 側脳室周囲のsubventricular zone (SVZ) と呼ばれる領域に起こり嗅球の中央に終わる. RMSを移動するニューロブラストは, 嗅球へ到達するとニューロンへと分化する. この移動と分化に必要な因子の同定は神経発達メカニズムの理解に重要なだけでなく, 神経再生に応用出来る可能性がある重要な課題である. RMSのニューロブラスト研究の歴史を概説するとともに, ニューロブラストに発現する接着因子に着冒して, その移動と分化の制御機構を明らかにしようと考えている私達の研究を紹介する. 続きを見る