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1.

論文(リポジトリ)

論文(リポジトリ)
山本, 正治 ; 真柄, 純子 ; 高木, 修子
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.159-161,  1990-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/33735
概要: The deaths from the female breast cancer show the marked international variation. Among advanced countries, the deaths in Japan are least frequent. In spite of this evidence, the breast cancer in Japan can not be ignored since it increases gradually. In the present symposium, a review of epidemiological studies was made in order to point out the risk factors, such as high socioeconomic status, fat consumption, obesity, nullipara and low fertility. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
佐野, 宗明
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.161-165,  1990-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/33739
概要: Techniques used to dignose the breast cancer were evaluated for correctness with 135 of the 150 cases which were treated at our clinic in 1988. Excluded were the 15 cases which underwent outside biopsy. The diameter of tumor mass was 2.0 cm or less in 67 and 2.1 cm or more in 68. By inspection and palpation, the basic examination, the diagnosis was established or suspicious in 83.7% of the 135 cases and established in 48.1%, where practically no further examination was necessary before mastectomy. The diagnosis was definite in 34.3% of the small lesions and 61.8% of large lesions. Mammography was definitely positive in 50.4% and positive or suspicious in 58.5%. Ultrasonic examination and cytologic examination by fine needle aspiration were performed in 69.6% and 67.4%. With tumors which were 2.0 cm or less in size, the ultrasonic examination was positive or suspicious in as high as 90.7% while definitely positive in only 27.9%, suggesting that latter rate may be raised if images are improved. Mastectomy was indicated based on physical examination and mammography in 19.3% and ultrasonic and cytologic examinations in 40.0%. Biopsy was further added before mastectomy in 40.7%. Biopsy was performed in 62.7% of the small masses while the rate rate for large ones was as low as 10.1%. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
稲越, 英機
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.169-174,  1990-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/33733
概要: Radiation therapy is an important treatment modality in the management of breast cancer patients. In 1970's, postoperative radiotherapy was claimed that it had increased the incidence of distant metastasis in early breast cancer. However, the dose and field of postoperative radiotherapy in the trials referred had been regarded as outdated in that era. As an adjuvant therapy, radiotherapy establishes control of subclinical diseases in the regional lymphnodes and may decrease the incidence of distant metastasis in high risk patients. As a conservative treatment modality, radiotherapy achieves locoregional control of 90% in early breast cancer. Also in selected bulky diseases, boosting interstitial temporary implants, such as iridium-192 seed assembly or wire, yield fair locoregional control and good aesthetic results. 続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
室橋, あゆみ ; 内山, 美枝子
出版情報: 新潟大学保健学雑誌 = 新潟大学保健学雑誌.  13  pp.1-9,  2016-09.  新潟大学医学部保健学科
本文リンク: http://hdl.handle.net/10191/44137
概要:  乳がんの化学療法で生じる脱毛に着目し,脱毛に対する看護支援について,国内外の文献から明らかにすることを目的とした。 文献検索の結果,医学中央雑誌では51件が該当し,その中から11件を対象とした。MEDLINEでは,57件が該当し,その中の 17件を対象とした。文献は,「がん看護コアカリキュラム」の脱毛時の看護支援を参考に,「心理的支援」,「身体的支援」,「開発支援」の項目に分けて報告内容を分類した。 「心理的支援」では,患者への情報提供(脱毛の機序・時期・再発毛)やボディイメージの変容に関する援助の報告がみられた。「身体的支援」では,整容,皮膚,頭髪以外の脱毛に関する援助と脱毛時の対処に関する援助の報告がみられた。「開発支援」では,脱毛の軽減や脱毛予防の検証報告が散見されたが,有効性を確証する報告はなかった。これらから,乳がんの化学療法で生じる脱毛の看護支援は,国内外とも未だ対症的な支援にとどまっており,脱毛時期に応じた系統的な看護支援まで行き着いていない実情が示唆された。<br /> Hair loss is a common side effect of chemotherapies used in the treatment of breast cancer. Hair loss affects the Quality of life (QOL) of women with breast cancer. In this study, we reviewed the literatures on hair loss that occurs during breast cancer therapy and intended to clarify the current status of nursing support for patient hair. The 27 out of 51 relevant papers returned from the website of Igaku Chuo Zasshi, and MEDLINE, were enrolled into the present study. The literature was categorized into “psychological support,”“physical support,”“psychological support for hair loss”, and “development support.” For “psychological support,” there were reports on the provision of information to patients on the mechanism and period of hair loss and the period of hair regrowth, as well as reports on changes in body image. For “physical support,” there were reports on concrete assistance other than cosmetic cleaning, skin, hair, and on handling of hair loss. For “development support,” there were no citations for a treatment clearly effective in preventing hair loss. These data suggest that the present support for hair loss from  chemotherapy used to treat breast cancer is still aimed at relieving the symptom and has not led to systematic support for patients suffering from this treatment side effect. 続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
SATO, Nobuaki ; OYAMATSU, Manabu ; KOYAMA, Yu ; HAYASHI, Mitsuhiro ; KANBAYASHI, Chizuko ; HATAKEYAMA, Katsuyoshi
出版情報: Acta medica et biologica = Acta medica et biologica.  48  pp.97-101,  2000-09.  Niigata University School of Medicine
本文リンク: http://hdl.handle.net/10191/1941
概要: Background : It has been recommended that breast cancer patients without clinical involvement of the axilla routinely undergo sentinel node biopsy to obtain important information about the status of the axillary nodes. However, positive internal mammary nodes (i.m.n.) have been documented in patients with histologically negative axillary lymph nodes. The aim of this study was to determine whether an i.m.n. could be the first lymph node to receive malignant cells from a breast tumor. Patients and methods : The incidence of i.m.n. metastasis was examined retrospectively in patients with T1 breast cancer. From 1965 to 1991,74 patients (mean age : 48 years) with T1 breast cancer underwent Halsted mastectomy with i.m.n. dissection at Niigata University Medical Hospital. The i.m.n. dissection included the internal mammary vessels and i.m.n. from the 2nd to the 4th intercostal space. Pathologic specimens were examined by hematoxylin and eosin staining. Results : The incidence of i.m.n. metastases was 12%. Among 5 patients in whom only one tumorpositive lymph node was identified, all had a positive axillary node. Conclusion : These results suggest it is highly unlikely an i.m.n. is the first lymph node to receive malignant cells from a breast tumor. 続きを見る
6.

論文(リポジトリ)

論文(リポジトリ)
小山, 諭 ; 畠山, 勝義
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  121  pp.622-625,  2007-11.  新潟医学会
本文リンク: http://hdl.handle.net/10191/32855
概要: The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor. Trastuzumab (Herceptin^[○!R]), a recombinant monoclonal antibody against HER2 has been becoming a key drug for HER2-overexpressed breast cancer, moreover to be used in ajuvant and neoadjuvant settings. 続きを見る
7.

学位論文(リポジトリ)

学位
Moro, Kazuki
出版情報: 2018-09-20.  新潟大学
本文リンク: http://hdl.handle.net/10191/50772
概要: Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death. Although important roles of sp hingolipids in breast cancer progression have been reported in experimental models, their roles in human patients are yet to be revealed. The aim of this study was to investigate the ceramide levels and its biosynthesis pathways in human breast cancer patients. Breast cancer, peri-tumor and normal breast tissue samples were collected from surgical specimens from a series of 44 patients with breast cancer. The amount of sphingolipid metabolites in the tissue were determined by mass spectrometry. The Cancer Genome Atlas was used to analyze gene expression related to the sphingolipid metabolism. Ceramide levels were higher in breast cancer tissue compared to both normal and peri-tumor breast tissue. Substrates and enzymes that generate ceramide were significantly increased in all three ceramide biosynthesis pathways in cancer. Further, higher levels of ceramide in breast cancer were associated with less aggressive cancer biology presented by Ki-67 index and nuclear grade of the cancer. Interestingly, patients with higher gene expressions of enzymes in the three major ceramide synthesis pathways showed significantly worse prognosis. This is the first study to reveal the clinical relevance of ceramide metabolism in breast cancer patients. We demonstrated that ceramide levels in breast cancer tissue were significantly higher than those in normal tissue, with activation of the three ceramide biosynthesis pathways. We also identified that ceramide levels have a significant association with aggressive phenotype and its enzymes have prognostic impact on breast cancer patients.<br />学位の種類: 博士(医学). 報告番号: 甲第4499号. 学位記番号: 新大院博(医)甲第836号. 学位授与年月日: 平成30年9月20日<br />Oncotarget. 2018, 9(28), 19874-19890.<br />新大院博(医)甲第836号 続きを見る