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論文(リポジトリ)

論文(リポジトリ)
本間, 照
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  106  pp.89-97,  1992-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/39533
概要: Immunohistological study by a monoclonal antibody against DNA polymerase α was made for the investigation of labeling in dex (LI) and proliferative zone in normal mucosa and tumors (-like lesions) of the colon and rectum (normal mucosa ; n=9, hyperplastic polyps ; n=6, tubular adenomas ; n=30 and intramucosal carcinomas ; n=3). The normal mucosa and hyperplastic polyps showed a similar distribution of proliferating cells, forming a proliferative zone which restricted to the lower portion of the crypt (up to about 200μm from the glandular base). In adenomas, the distribution of proliferating cells differed by size ; small tubular adenomas, 5mm or less in size, had proliferative zone in the upper portion of neoplastic tubules (down to 200~400μm from the surface), oppositely to that of the non-neoplastic mucosa. While tubular adenomas more than 5mm showed even distribution of proliferative cells along the whole length of the tubules. In all three mucosal carcinomas, the distribution pattern was similar to that of the latter-group adenomas. The LIs was not significantly different between the proliferative zone of normal mucosa (60.8±6.6), and that of adenomas (small ; 64.6±1.6, larger ; 62.5±5.6). But in carcinomas, it was significantly higher (77.8±0.7). The formation of proliferative zone in small adenomas like non-neoplastic mucosa (but opposite location), suggests that they have a lower potential of proliferation. But the different distribution-patterns of proliferating cells in the larger adenomas indicates that the proliferating activity changes as adenomas grow. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
Ajioka, Yoichi ; Watanabe, Hidenobu ; Kobayashi, Masaaki ; Yoshida, Mituhiro ; Genta, Robert M.
出版情報: Acta medica et biologica = Acta medica et biologica.  43  pp.63-68,  1995-06.  Niigata University School of Medicine
本文リンク: http://hdl.handle.net/10191/33199
概要: 8624 tubular adenomas from 9 patients with familial adenomatosis coli were investigated to elucidate the mode of their macroscopic development. Our data indicate that most tubular adenomas remain smaller than 5 mm, suggesting that those larger than 5 mm detected clinically may already have deviated from the expected natural history of benign adenomas. Their initial macroscopic configuration appears to be the flat or sessile type, and they seem to change their macroscopic configurations to subpedunculated as they attain a size between 5 and 7 mm. Adenomas larger than 8 mm appear to take a pedunculated shape. This mode of macroscopic development may be affected by the location of adenomas, and tends to occur in adenomas of a smaller size in the rectum, sigmoid and ascending colon than in the rest of the organ. 続きを見る