Blank Cover Image

線条体内スルピリド濃度変化とカタレプシーとの関係 : In vivo voltammetryを用いた研究

フォーマット:
論文(リポジトリ)
責任表示:
堀川, 洋 ; 那波, 宏之
出版情報:
新潟医学会, 1997-05
掲載情報:
新潟医学会雑誌 — 新潟医学会雑誌
ISSN:
00290440  CiNii Research  Webcat Plus  JAIRO
著者名:
巻:
111
通号:
5
開始ページ:
319
終了ページ:
327
概要:
To investigate the relationship between striatal dopaminergic function and behavior, we simultaneously examined the intrastriatal kinetics of the dopamine antagonist sulpiride and cataleptic behavior using in vivo voltammetry. First, we con firmed that sulpiride, a D2 antagonist, could be measured in vivo with this technique. Sulpiride current intensity was measured when the potential was increased from 750 to 850 mV. Then sulpiride was administered into the striatum of freely moving rats. Sulpiride levels increased and remained high for more than 3h. Cataleptic behavior also continued for 3h. The duration of cataleptic behavior correlated well with that increase in sulpiride. Sulpiride kinetics was compared with that of dopamine and 1-methyl-1, 4-phenylpyridi-nium(MPP+). Dopamine and MPP+ were administered intrastriatally and were taken up into dopaminergic neurons within 1h after the end of injection. These findings suggest that sulpiride is not taken up or metabolized. 続きを見る
E-Resources:
本文リンク
タイトルが類似している資料

類似資料:

1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
11
 
12
 

那波, 宏之

新潟日報事業社

2 図書 線条体

板倉, 徹(1946-), 前田, 敏博

ブレーン出版

飯島, 友也

新潟医学会

飯島, 友也

新潟大学

芹澤, 正博, 星野, 嘉恵子, 平野, 茂樹, 車田, 正男

新潟医学会

車田, 正男

新潟医学会

12 論文(リポジトリ) 加齢および痴呆と基底核

小柳, 清光, 生田, 房弘

新潟医学会