| 1.
論文(リポジトリ) |
論文(リポジトリ)
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羽生, 忠正
概要:
To study joint destruction and osteoporosis in patients with rheumatoid arthritis (RA), we investigated bone loss using
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histomorphometric analysis. We also examined the property of colony forming unit-fibroblastic (CFU-F) isolated from tibial bone marrow in rats with collagen-induced arthritis (CIA) and iliac bone marrow in human. Our findings showed decreases of parameters of bone formation and of the number of alkaline phosphatase-positive CFU-F during onset of arthritis. We speculated that reduced bone formation was the predominant mechanism of bone loss in the pathogenesis of RA. We also demonstrated that the lymphocytes in the joints of CIA comprised resident T cells that are extrathymically generated in situ. In vivo treatment with various monoclonal antibody, these γδT cells and CD 8 _<αα>^+ cells were associated with suppression of the disease, especially after its onset. On the other hand, in patients with RA, CD57^+T cells levels were elevated, especially high in joints and its adjacent bone marrow. CD57^+T cells contained higher proportions of CD ^4-^8- cells and γδT cells than CD57^-T cells. We suggested that CD57^+T cells with NK cell marker probably were a counterpart of extrathymic T cells in human and had unique immuno-suppressive functions. In rats with CIA, great increase in number of granulocytes were also observed before the onset of arthritis. From these results, we are performing the evaluation of these treatment which makes it possible to decrease the granulocytes or to increase the CD57^+T cells using previous analysis system of bone formation.
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| 2.
論文(リポジトリ) |
論文(リポジトリ)
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菊池, 透 ; 橋本, 尚士 ; 川崎, 琢也 ; 内山, 聖
概要:
The effects of growth hormone (GH) on bone metabolism were studied in 8 GH-deficient children. Biochemical markers for b
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one metabolism, such as osteocalcin, alkakine phoshatase (ALP), insulin like growth factor-I (IGF-I), calcium, phosphate, renal tubular reabsorption of phosphate (%TRP), vaitamin D_3, parathyroid hormone (PTH) and calcitonin, and bone mineral density (BMD) were measured before and 1, 2, 3, 6, 9, 12 months after treatment with GH. BMD was determined by dual energy X-ray absorptiometry at 2nd～4th lumbar spine by using a model QDR 1,000 (Hologic Corp., Waltham, Massachusetts). All children had significant increment of body height (BH) SD score, height velocity and height velocity SD score. We compared these makers and BMD of pretreatment with those of posttreatment. The following results were obtained. 1) Significant increment of osteocalcin, ALP and IGF-I serum level were found. 2) Serum levels of Calcium and phosphate, and %TRP showed a tendency to increase. 3) Serum level of 1,25-(OH)_2 vaitamin D_3 showed a tendency to increase. However serum levels of 25-(OH) vaitamin D_3 and 24,25-(OH)_2 vaitamin D_3 showed a tendency to decrease. 4) No significant chages in PTH C-terminal and calcitonin levels were found. 5) A significant increment of BMD was found. However no significant variation of BMD/BH was found. Bone metabolism is regulated by numerous hormones and local growth factors. Our findings suggest that the treatment with GH may affect this network of bone metabolism and stimulat bone turnover, especially bone formation.
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| 3.
論文(リポジトリ) |
論文(リポジトリ)
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川島, 博行
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