肝類洞で起こる胸腺外Tリンパ球分化

フォーマット:

論文(リポジトリ)

責任表示:

安保, 徹

出版情報:

新潟医学会, 1991-12

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

安保, 徹  

巻:

105

通号:

12

開始ページ:

777

終了ページ:

785

概要:

There exists a considerable number of unique T lymphocytes in the periphery in congenitally athymic nude mice, and in aged humans and animals with the involuted thymus. It is, therefore, suggested by several investigators that the extrathymic pathway of T cell differentiation may be present somewhere. We have recently demonstrated that such extrathymic T cell differentiation occurs in the hepatic sinusoids in humans and mice. This pathway of T cell differentiation … resides phylogenetically earlier than the intrathymic pathway of T cell differentiation. Before and after thymic development, extrathymic T cells might work as the surveillance system for atypical cells generated in vivo by virture of their autoreactivity. Extrathymic T cells have α β TcR (and γ δ TcR) of intermediate intensity and contain many autoreactive T cell clones. The existence of the hepatic pathway could clearly explain the phenomenon “breakdown of self-tolerance”, and occupies an important position of the immunology for aging, autoimmine disease, malignancy, bacterial infection, transplantation and allergy (immediate hypersensitivity). 続きを見る

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