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1.

論文(リポジトリ)

論文(リポジトリ)
本間, 照
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  106  pp.89-97,  1992-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/39533
概要: Immunohistological study by a monoclonal antibody against DNA polymerase α was made for the investigation of labeling in dex (LI) and proliferative zone in normal mucosa and tumors (-like lesions) of the colon and rectum (normal mucosa ; n=9, hyperplastic polyps ; n=6, tubular adenomas ; n=30 and intramucosal carcinomas ; n=3). The normal mucosa and hyperplastic polyps showed a similar distribution of proliferating cells, forming a proliferative zone which restricted to the lower portion of the crypt (up to about 200μm from the glandular base). In adenomas, the distribution of proliferating cells differed by size ; small tubular adenomas, 5mm or less in size, had proliferative zone in the upper portion of neoplastic tubules (down to 200~400μm from the surface), oppositely to that of the non-neoplastic mucosa. While tubular adenomas more than 5mm showed even distribution of proliferative cells along the whole length of the tubules. In all three mucosal carcinomas, the distribution pattern was similar to that of the latter-group adenomas. The LIs was not significantly different between the proliferative zone of normal mucosa (60.8±6.6), and that of adenomas (small ; 64.6±1.6, larger ; 62.5±5.6). But in carcinomas, it was significantly higher (77.8±0.7). The formation of proliferative zone in small adenomas like non-neoplastic mucosa (but opposite location), suggests that they have a lower potential of proliferation. But the different distribution-patterns of proliferating cells in the larger adenomas indicates that the proliferating activity changes as adenomas grow. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
味岡, 洋一 ; 渡辺, 英伸
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  102  pp.727-733,  1988-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/41061
概要: Macroscopic differential diagnosis of colorectal cancers was discussessed based on the results of the histological and m acroscopic observation of 1842 advanced cancers, early cancers and adenomas. Among the neoplastic lesions in colon and rectum in our series, 95.3% of those measured more than 30mm in the largest diameter were advanced cancers, and none was advanced those less than 10mm. Lesions between 10mm to 30mm, about a half of the polypoid lesions more than 25mm was advanced cancers, and 96.5% of the lesions in size more than 15mm was advanced if central depression be present. An certain numbers of early cancers were well discriminated from adenomas by the statistical analysis based on the relationship between size and macroscopic configuration of the lesions; that flat and sessile lesion more than 10mm and, subpedunculated and pedunculated lesions more than 15mm were suspectable of being early cancers. Among them flat and peduculated lesion have high possibility of mucosal cancer and, sessile and subpedunculated, of submucosal cancer. Submucosal cancers were also well detectable to recognize their specific surface apappearance and the amount of their invasion was also able to estimate to notice the evertion of non-neoplastic mucosa surrounding the lesions. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
味岡, 洋一
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.131-142,  1990-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/33676
概要: Macroscopic differential diagnosis between adenoma and carcinoma and histogenesis of carcinoma of the colon and rectum were studied on 2102 advanced carcinomas, early carcinomas and adenomas. For the macroscopic differential diagnosis, size and gross configuration of lesions played important roles. Any lesions more than 30mm in size, polypoid lesions more than 25mm, and depressed lesions more than 10mm were advanced carcinomas. Excluding the advanced cancers, it would be reasonable to consider the following lesions as submucosal carcinomas, i.e. depressed or sessile lesions more than 15mm in size and the subpedunculated more than 20mm. Flat or pedunclulated lesions had less possibility of being submucosal carcinomas, and they were intramucosal carcinomas, at the size of more than 10mm. Submucosal carcinomas were well diagnose macroscopically by their characteristics of surface appearance at the accuracy of 73.1%. For the histogenesis of the colorectal carcinomas, 75.9-85.3% of intramucosal carcinomas were estimated to originate from benign adenoma. The malignancy rate of adenomas were affected by their size. It showed rapid increase in proportion to size until 15mm, and reached the plateau at the size of more than 15mm. 続きを見る