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堀あきこ著
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| 2.
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図書
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牟田和恵編
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| 3.
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日本政治学会編
目次情報:
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| 4.
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陳一吟著
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日本社会保障法学会編
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| 6.
図書 |
図書
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久保田竜子著
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| 7.
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三浦清一郎著
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| 8.
図書 |
図書
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田中冨久子著
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| 9.
論文(リポジトリ) |
論文(リポジトリ)
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押阪, 裕之
概要:
Fibronectin (FN) is a glycoprotein of large molecular weight that is present on most cell surfaces and in plasma. Fibron
…
ectin functions in many areas, such as cell-matrix or cell to cell adhesion, mobilization and differentiation of cells, opsonization, and tissue repair. In this study, plasma fibronectin (p-FN) values of 348 subjects from newborns to adults were measured in an effort to examine the differences in ages and sexes. Results：(1) Fibronectin values during the newborn period were 60 to 70% those of the adult period, increased as the child drew and reached the adult value at the age of 10 years. (2) There were no differences in p-FN values between sexes until 10 years old, thereafter, female values were 10 to 15% less those of the male. (3) There were correlative tendencies in newborn babies between gestational weeks and plasma fibronectin concentrations. (4) For evaluation of plasma fibronectin values, it is necessaary to consider the subject's age and sex, particularly in children, whose fibronectin values are lower than those of adults.
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| 10.
論文(リポジトリ) |
論文(リポジトリ)
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木村, 元彦
概要:
Male predominance of malignant disease and female predominance of autoimmune disease are widely known in humans. To eluc
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idate one of the underlying mechanisms, we examined whether sex differences exist at the level of extrathymic T cells in various organs of mice under physiological conditions. Effects of orchiectomy or testosterone administration were also examined. Extrathymic T cells expressing CD3 of intermediate intensity (i. e., intermediate TCR cells) and a high level of IL-2 receptor β-chain (IL-2Rβ), and thymusderived T cells expressing of TCR of bright intensity (i. e., bright TCR cells) and lacking IL-2Rβ, were identified by immunofluorescent tests. Of each three strain tested, it was demonstrated that intermediate TCR cells were much more predominant in the liver and some other organs in female mice than in male mice. In the liver of orchiectomied mice, the number of mononuclear cells increasod and intermediate TCR cells became predominant as if the mice were female. Testosterone replacement canceled the immunological effect of orchiectomy. Considering the fact that extrathymic T cells comprise a considerable proportion of self-reactive forbidden clones and possess cytotoxic activity aganinst syngenic tumor cells, the present results might suggest a possible relationship between physiologically low levels of extrathymic T cells and the male predominance of malignancy.
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