生殖細胞の腫瘍化とその特性 : 卵黄嚢（ヨークサック）腫瘍の今日的視点

フォーマット:

論文(リポジトリ)

責任表示:

本山, 悌一

出版情報:

新潟医学会, 1991-03

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

本山, 悌一  

巻:

105

通号:

3

開始ページ:

155

終了ページ:

161

概要:

Mouse embryonal carcinoma cells have been studied extensively on cell differentiation, and are regarded as the stem cells of teratocarcinoma. However, it seems that the hypotheses on histogenesis of human germ cell tumors have followed the mouse tumor model too much. The characters of human embryonal carcinoma cells still remain unclear. Human embryonal carcinoma cells behave differently from mouse embryonal carcinoma cells in many aspects. Using human … germ cell tum or cell lines in vivo and in nude mice, I successfully found that some of the human embryonal carcinoma, which were made a diagnosis in the customary way, belonged to undifferentited forms of yolk sac tumor correctly. A rat tumor model also supported my consideration. Moreover, I confirmed that yolk sac tumor cells had a potential of neoplastic metaplasia to the intestinal epithelium. 続きを見る

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