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図書 |
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宮園浩平, 菅村和夫編
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| 2.
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図書
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笠倉新平編集
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| 3.
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図書
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笠倉新平, 松島綱治編集
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| 4.
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図書
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宮沢恵二, 伊東進企画
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図書
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今西二郎編
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| 6.
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図書
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大沢利昭編
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| 7.
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図書
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笠倉新平編集
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| 8.
論文(リポジトリ) |
論文(リポジトリ)
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藤中, 秀彦 ; 山本, 格
概要:
CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of
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monocytes/macrophages (Mo/Mφ) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/Mφ in the glomeruli was examined. ICAM-1 expression and Mo/Mφ accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/Mφ were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/Mφ accumulation. Expression of mRNA for IL-1β, TNFα and IFNγ, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1β. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNFα and IFNγ and play a role in the accumulate Mo/Mφ.
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| 9.
論文(リポジトリ) |
論文(リポジトリ)
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岡田, 正彦
概要:
We investigated what the possible mediators or conditions that accelerate the expression of cellular adheison molecules
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on cultured endothelial cells are. Examined factors were native low density lipoprotein (LDL), oxidized LDL, glycated LDL, LDL-autoantibody immune complexes, and hypoxia. Adhesion molecules were ELAM-1, ICAM-1, ICAM-2, and VCAM-1. The present study showed that oxidized LDL, glycated LDL, LDL-autoantibody complexes, and hypoxia were mediaters that caused the expression of ELAM-1. It was also found that TNFα played a key role in the sequence.
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| 10.
論文(リポジトリ) |
論文(リポジトリ)
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冨田, 善彦
概要:
Incidence and mortality rates of renal cell carcinoma (RCC) in Japan are increasing and approximately 3000 person died of RCC. Radical surgical removal of small RCC, frequently denoted as less than 4 cm, leads to favorable
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prognosis. On the contrary, virtually all patients with metastasis succumb to the disease partly because RCC is refractory to chemotherapy or irradiation. RCC has unique character including rather frequent spontaneous regression cases reported, rather higher response rates to administration of cytokines. These indicate needs for brand new treatment strategy based on the individual properties of each RCC.
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