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図書 |
図書
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渡部久実研究代表
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論文(リポジトリ) |
論文(リポジトリ)
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渡部, 久実 ; 宮路, 智香子 ; 宮川, 亮子 ; 安保, 徹 ; 佐藤, 好信 ; 山本, 智 ; 飯合, 恒夫 ; 黒崎, 功 ; 白井, 良夫 ; 畠山, 勝義 ; 市田, 隆文 ; 野本, 実 ; 土屋, 淳紀 ; 石本, 結子 ; 朝倉, 均
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| 3.
論文(リポジトリ) |
論文(リポジトリ)
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久保田, 茂夫 ; 柴田, 実 ; 山村, 倉一郎 ; 三輪, 仁 ; 松崎, 浩徳 ; 生沼, 武男 ; 渡部, 久実
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| 4.
論文(リポジトリ) |
論文(リポジトリ)
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渡部, 久実
概要:
Many functions of cells of the immune system are mediated through the production of cytokines. CD4+ helper T cells diffe
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rentiate functionally into one of two subsets, Th1 or Th2. Th1 cells generate IL-2 and IFNγ and support the cellular immune responses. On the other hand, Th2 cells generate IL-4, IL-5 and IL-10 and support the humoral immune responses. A unique population of T cells that carry intermediate levels of TCR exist in the liver and other immune organs. These T cells express IL-2Rβ-chain and receptors of the NK cell lineage. Many investigators call them intTCR cells or NKT cells. Recently, it was demonstrated that NKT cells produce IL-4 and IFN-γ and regulate the differentiation of CD4^+ helper T cells into Th1 or Th2 cells. These findings indicate that NKT cells play an important role of immune regulation by cytokines.
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| 5.
論文(リポジトリ) |
論文(リポジトリ)
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富山, 智香子 ; 石本, 結子 ; 塚田, 知香 ; 横山, 恒 ; 宮川, 亮子 ; 菅原, 聡 ; 山際, 諭 ; 楊, 秀華 ; 渡部, 久実 ; 佐藤, 好信 ; 市田, 隆文 ; 安保, 徹 ; 朝倉, 均
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論文(リポジトリ) |
論文(リポジトリ)
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陳, 煒 ; 柴田, 実 ; 張, 晶 ; 冉, 維志 ; 小坂, 健之 ; 久保田, 茂夫 ; 渡部, 久実
概要:
Allo-tissue or-organ such as skin or joint transfer requires to induct an efficient immunological suppression with less
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side effects than those of the present vital organ transfer. We conducted allo-skin grafting using rats with major histocompatibility mismatching. A full thickness abdominal skin of the Lewis rat, 1.5×2.0 cm in size, was harvested and grafted on to the back of Brown Norway rat. We inducted immunological tolerance using daily injection of 2 mg/kg anti-CD 2 monoclonal antibodies to the recipient BN rat starting from one day before surgery until 7 days postoperation except the day of the surgery. We also treated the immunogenecity of the grafting donor skin with cryopreservation. The donor skin grafts were soaked in 1.4 mol glycerol solution for tissue protection and frozen in step wise using programming freezer and then preserved in liquid nitrogen tank for 21 days before grafting. The results were evaluated by the close observation of the grafted skin condition, and the immunological conditions were assessed by flow cytometry and mixed lymphocyte reaction (MLR) test. The grafted cryopreserved skin was rejected 17 days postoperatively in average in anti-CD 2 MoAb administrated rats and 14 days in rats without anti-CD 2 MoAb administration. There was no hair regrowth in the skin grafted area which underwent rejection and re-epithelialization suggesting the presence of the dermis of the grafted skin in half of the rats treated with cryopreservation, and only one in rats without cryopreservation 4 months postoperatively. Flow cytometry and MLR test suggested that immunological tolerance was partly established. These results suggests that combined treatment of the recipient using anti-CD 2 MoAb and that of donor by cryopreservation may establish an effective immunological tolerance in allo-skin grafting.
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論文(リポジトリ) |
論文(リポジトリ)
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亀山, 仁史 ; 川村, 俊彦 ; 内藤, 哲也 ; 坂内, 誠 ; 渡部, 久実 ; 安保, 徹
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論文(リポジトリ) |
論文(リポジトリ)
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橋立, 英樹 ; 渡辺, 英伸 ; 味岡, 洋一 ; 西倉, 健 ; 安保, 徹 ; 渡部, 久実 ; 宮川, 亮子 ; 内藤, 哲也 ; 菅原, 聡 ; 良田, 裕平 ; 相場, 恒男
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| 9.
論文(リポジトリ) |
論文(リポジトリ)
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小川, 充 ; 飯合, 恒夫 ; 渡部, 久実 ; 安保, 徹
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| 10.
論文(リポジトリ) |
論文(リポジトリ)
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渡部, 久実 ; 飯合, 恒夫 ; 安保, 徹
概要:
Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells
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were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity.
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