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図書 |
図書
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小澤哲夫
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論文(リポジトリ) |
論文(リポジトリ)
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小澤, 哲夫
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論文(リポジトリ) |
論文(リポジトリ)
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赤井, 卓也 ; 山本, 謙二 ; 飯塚, 秀明 ; 柿沼, 宏明 ; 川上, 重彦 ; 小澤, 哲夫
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| 4.
論文(リポジトリ) |
論文(リポジトリ)
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中島, 孝 ; 小澤, 哲夫 ; 伊藤, 博明 ; 後藤, 清恵
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| 5.
論文(リポジトリ) |
論文(リポジトリ)
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佐藤, 匡 ; 丸山, 弘樹 ; 鈴木, 紀夫 ; 本間, 智子 ; 小澤, 哲夫 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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| 6.
論文(リポジトリ) |
論文(リポジトリ)
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菊池, 正俊 ; 青木, 薫 ; 関口, 秀隆 ; 吉田, 桂 ; 高橋, 知香子 ; 中園, 清 ; 村澤, 章 ; 小澤, 哲夫 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
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| 7.
論文(リポジトリ) |
論文(リポジトリ)
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野沢, 悟 ; 小澤, 哲夫 ; 星野, 賢一 ; 山崎, 秀 ; 石川, 肇 ; 中園, 清 ; 村澤, 章 ; 鈴木, 栄一 ; 荒川, 正昭
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| 8.
論文(リポジトリ) |
論文(リポジトリ)
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中野, 正明 ; 小澤, 哲夫 ; 菊池, 正俊 ; 荒川, 正昭 ; 山田, 俊幸 ; 羽生, 忠正 ; 佐藤, 健比呂 ; 中園, 清 ; 村澤, 章
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| 9.
論文(リポジトリ) |
論文(リポジトリ)
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中野, 正明 ; 伊藤, 聡 ; 本間, 智子 ; 小澤, 哲夫 ; 菊池, 正俊 ; 佐藤, 健比呂 ; 荒川, 正昭
概要:
Comparative studies of clinical, laboratory and immunological findings were performed for 134 rheumatoid arthritis (RA) patients in relation to several extra-articular features. There were 22 cases of malignant RA (MRA) or RA with
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interstitial pneumonia. The titers of rheumatoid factor (RF) determined by enzyme linked immunosorbent assay were significantly higher in sera from these RA patients than in sera from RA patients without extra-articular features. Seventeen RA patients were complicated by secondary amyloidosis. In this group, proteinuria and impairment of renal function were observed frequently. Concurrence of RA and other collagen vascular diseases were observed in 18 patients. In this group, hypocomplimentemia and hypergammaglobulinemia were observed frequently. RA with biopsy-proven renal disease were observed in 30 patients. Laboratory results of this group revealed characteristic findings, namely lower concentrations of CRP and RF compared with those of other groups. These results suggest that inflammatory and immunological mechanisms may not have any major role in the pathogenesis of nephropathy in patients with RA, contrary to their role in other extra-articular manifestations experienced in MRA patients.
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| 10.
論文(リポジトリ) |
論文(リポジトリ)
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菊池, 正俊 ; 小澤, 哲夫 ; 佐藤, 健比呂 ; 中野, 正明 ; 荒川, 正昭
概要:
Systemic lupus erythematosus (SLE) is characterized by production of many autoantibodies. The clinical significance of the autoantibodies, especially anti-DNA antibody and antiphospholipid antibodies, was discussed in this paper.
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Anti-dsDNA antibody is highly specific for SLE and rarely seen in a significant titer in other rheumatic diseases. This antibody is useful for assessing desease activity. It can bind to several cellular components or bacterial polysaccharides, which suggest that the restricted anti-DNA antibody may account for the serological abnormalities and the tissue injury in SLE. Anti-phospholipid antibodies include BFP-STS, lupus anticoagulant, anti-cardiolipin antibody and anti-phosphatidyl serine antibody. These antibodies had a significant correlation with fetal wastage, thrombocytopenia, CNS lupus and thrombosis. We observed 3 patients who had successful pregnancies after anti-phosphatidyl serine antibody reduced to normal level. Anti-phpsphatidyl serine antibody is surely useful for the management of pregnancy in lupus patients.
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