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1.

図書

図書
谷川久一監修 : 内藤眞, 市田隆文編
出版情報: 東京 : アークメディア, 1999.12
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2.

図書

図書
研究代表者内藤眞
出版情報: [新潟] : [内藤眞], 2003.3
シリーズ名: 科学研究費補助金(基盤研究(C)(2))研究成果報告書 ; 平成13年度〜平成14年度
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3.

図書

図書
研究代表者内藤眞
出版情報: [新潟] : [内藤眞], 2001.3
シリーズ名: 科学研究費補助金基盤研究(C)(2)研究成果報告書 ; 平成11年度〜平成12年度
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4.

論文(リポジトリ)

論文(リポジトリ)
内藤, 眞 ; 高塚, 尚和 ; 長谷川, 剛 ; 伊藤, 重雄 ; 児玉, 龍彦
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  110  pp.216-227,  1996-06.  新潟医学会
本文リンク: http://hdl.handle.net/10191/43115
概要: In order to clarify the expression and tissue distribution of scavenger receptors, we have performed immunohistochemical and immunoelectron microscopical studies as well as in situ hybridization. Scavenger receptors are a trimeric glycoprotein mediating endocytosis of chemically modified low density lipoproteins (LDL). The receptors were detected specifically in macrophages in various tissues by immunohistochemistry using anti-bovine scavenger receptor monoclonal antibody IgG-D2, although hepatic sinusoidal cells are known to incorporate modified LDL actively. In contrast, scavenger receptor protein was detected both in Kupffer cells and endothelial cells of the hepatic sinusoid and lymphatic sinus by immunohistochemistry using anti-bovine scavenger receptor antibody IgG-D1 and anti-murine scavenger receptor antibody 2F8. In situ hybridization demonstrated the expression of scavenger receptor mRNA in Kupffer cells and sinusoidal endothelial cells. Scavenger receptors were not expressed in endothelial cells of other tissues than the liver and lymph nodes. These findings indicate that scavenger receptors are expressed both in macrophages and specific endothelial cells and that endothelial cells in various tissues constitute heterogeneous populations with regard to lipoprotein metabolism. 続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
梅津, 哉 ; 内藤, 眞 ; 木村, 格平
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  110  pp.72-77,  1996-02.  新潟医学会
本文リンク: http://hdl.handle.net/10191/42907
概要: Serous cystic neoplasms of the pancreas have been regarded as uniformly benign in biologic behavior. However, serous cystadenocarcinoma of the pancreas has been recently recognized as a new entity. We present a case of serous cystadenocarcinoma of the pancreas developed in a 68 year-old woman. The resected tumor showed a microcystic appearance with edematous cut surface. The epithelial cells of the cysts were cuboidal in shape, had clear cytoplasm and focal papillary projections, and were positive for PAS staining and negative for PAS with diastase digestion, Alcian blue or mucicarmine staining. Immunohistochemical stainings suggested the duct cell or centroacinar cell origin of this tumor. Although these findings as well as slight atypia were consistent with those of serous cystadenoma of the pancreas, metastatic foci were found in the peripancreatic and paracholedocal lymph nodes. These findings indicated that the present tumor was a rare case of serous cystadenocarcinoma of the pancreas accompanying mild cell atypia and lymph node metastases. 続きを見る
6.

論文(リポジトリ)

論文(リポジトリ)
内藤, 眞 ; 薄田, 浩幸 ; 梅津, 哉 ; 高塚, 尚和
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  110  pp.1-12,  1996-01.  新潟医学会
本文リンク: http://hdl.handle.net/10191/42751
概要: "Osteopetrotic(OP/OP) mouse is an animal model for osteopetrosis and was demonstrated to be a mutation within the coding region of M-CSF gene itself. The OP/OP mouse serves as a model for investigating the differentiation mechanism of macrophage populations in the absence of functional M-CSF. The OP/OP mice also provide evidence to show the role of M-CSF in physiological and pathological conditions. The OP/OP mice are severely monocytopenic and show marked reduction and abnormal differentiation of tissue macrophages and osteoclasts. Most of these macrophages are ultrastructurally immature. Compared with the tissues of normal littermates, those of mutants contained about 30% of macrophages in many tissues, suggesting that the heterogeneity of macrophages is generated by their different dependency to M-CSF. In contrast, the numbers of dendritic cells in the epidermis and lymphoid apparatus of OP/OP mice were not reduced comparing to those in normal littermates, indicating that dendritic cells are an M-CSF-independent population. After daily M-CSF injection the numbers of monocytes, tissue macrophages, and osteoclasts showed remarkable increases and macrophages demonstrated morphological maturation. However, the numbers of macrophages in the ovary and uterus were not increased. After glucan injection hepatic granulomas in OP/OP mice were formed but smaller, less numerous, and more irregular in shape than those of normal littermates. Kupffer cells in the mutant mice exhibited an active proliferation\ncapacity, particularly just before the stage of granuloma foration. After administration of M-CSF, numbers of monocytes and Kupffer cells increased rapidly in OP/OP mice and granuloma formation was enhanced in these mice. These results indicate that M-CSF-independent Kupffer cells and M-CSF-dependent macrophage populations play an important role in granuloma formation. In conclusion, M-CSF is an important molecule for proliferation and differentiation of not only M-CSF-dependent macrophages but also M-CSF-independent macrophages in\nphysiological conditions. Furthermore, M-CSF is largely responsible for providing a microenvironment for generating macrophage heterogeneity in vivo. " 続きを見る
7.

論文(リポジトリ)

論文(リポジトリ)
米山, 博之 ; 村井, 政子 ; 松島, 綱治 ; 鈴木, 健司 ; 朝倉, 均 ; 長谷川, 剛 ; 内藤, 眞 ; 松野, 健二郎
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  115  pp.23-24,  2001-01.  新潟医学会
本文リンク: http://hdl.handle.net/10191/48040
8.

論文(リポジトリ)

論文(リポジトリ)
小田島, 貴行 ; 長谷川, 剛 ; 石黒, 卓朗 ; 内藤, 眞
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  114  pp.308-311,  2000-08.  新潟医学会
本文リンク: http://hdl.handle.net/10191/49091
概要: We report a case of a 58-year-old Japanese man who developed splenomegaly and B-cell non-Hodgkin's lymphoma during the course of chronic hepatitis C. Although the etiological role of hepatitis C virus in the development of malignant lymphoma remains to be clarified, the relationship between hepatitis C infection and primary splenic malignant lymphoma was suggested. 続きを見る
9.

論文(リポジトリ)

論文(リポジトリ)
古泉, 直也 ; 木原, 好則 ; 酒井, 邦夫 ; 斎藤, 友雄 ; 森田, 哲郎 ; 奥泉, 美奈 ; 楚山, 真樹 ; 大和, 靖 ; 内藤, 眞 ; 江村, 巌 ; 相馬, 孝博
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  114  pp.277-277,  2000-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/49048
10.

論文(リポジトリ)

論文(リポジトリ)
堀川, 伸介 ; 古泉, 直也 ; 酒井, 邦夫 ; 奥泉, 美奈 ; 木原, 好則 ; 内藤, 眞 ; 梅津, 哉 ; 土田, 正則 ; 大和, 靖
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  114  pp.282-282,  2000-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/49046