close
1.

論文(リポジトリ)

論文(リポジトリ)
中澤, 俊郎
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  109  pp.340-352,  1995-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/42516
概要: The mechanism of diarrhea induced by Clostridium difficile (CD) toxin is not fully understood although that by Cholera toxin is sufficiently done. Present experiment aims to clarify its mechanism. Male Wistar rats weighing about 200 g were used, and CD toxin were injected into the lumen of ligated jejunal loops. First, time course study of histological examination and measurement of fluid accumulation in the ligated loops were carried out from 2 to 10 hours after CD toxin exposure. Second, we studied the changes of the activities of microvillus membrane enzymes and intestinal absorption rates of oligopeptides. Third, we studied the changes of activities of two intracellular mediators, protein kinase C (PKC) which is activated by diacylglycerol, and inositol 1-4-5-trisphosphate (IP_3) which releases Ca^<++> from endoplasmic reticulum. Diacyiglycerol and IP_3 are produced by receptor mediated-inositolphospholipid turnover. Luminal fluid accumulation steadily increased from 2 to 10 hours after CD toxin exposure. Slight damage in villus tips was observed 2 hours after exposure, and the change became more severe with time. Leucine aminopeptidase (LAP) activity was significantly decreased at 2 hours. The absorption rates of peptides were markedly decreased in toxin treated rats as compared with control rats using the jejunal perfusion method. Activity of PKC was significantly increased at 30 minutes, and that of IP_3 was also increased 1 hour after CD toxin exposure. In addition, PKC antagonist, staurosporin, inhibited the toxin induced-fluid accumulation. Calmodulin antagonists, trifluoperazine and chlorpromazine, also inhibited it. These results indicate that CD toxin increased inositolphospholipid turnover with subsequent activation of PKC and IP_3 in epithelial cell. Then inositolphospholipid turnover and Ca^<++> mobilization possibly play a synergistic role in inhibition of LAP and peptide carrier protein synthesis. Consequently inhibition of LAP synthesis and disturbance of peptide absorption may partly contribute to the CD toxin induced diarrhea. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
小林, 康雄 ; 杉本, 不二雄 ; 関矢, 忠愛 ; 斉藤, 六温 ; 植木, 匡 ; 中澤, 俊郎 ; 矢野, 雅彦 ; 森田, 哲郎
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  114  pp.321-321,  2000-08.  新潟医学会
本文リンク: http://hdl.handle.net/10191/49121
3.

論文(リポジトリ)

論文(リポジトリ)
中澤, 俊郎 ; 能澤, 明宏 ; 桶井, 一郎 ; 小林, 勲 ; 和栗, 暢生 ; 柏村, 浩 ; 西倉, 健
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  112  pp.284-284,  1998-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/45858
4.

論文(リポジトリ)

論文(リポジトリ)
須田, 和敬 ; 杉本, 不二雄 ; 関矢, 忠愛 ; 斉藤, 六温 ; 飯合, 恒夫 ; 能沢, 明宏 ; 中澤, 俊郎
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  112  pp.293-293,  1998-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/45894
5.

論文(リポジトリ)

論文(リポジトリ)
武井, 伸一 ; 本間, 照 ; 杉村, 一仁 ; 成澤, 林太郎 ; 青柳, 豊 ; 朝倉, 均 ; 味岡, 洋一 ; 阿部, 実 ; 中澤, 俊郎
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  113  pp.435-436,  1999-09.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46864
6.

論文(リポジトリ)

論文(リポジトリ)
笹川, 哲哉 ; 滝澤, 英昭 ; 中澤, 俊郎 ; 朴, 鐘千 ; 成澤, 林太郎 ; 上村, 朝輝 ; 朝倉, 均
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  104  pp.888-888,  1990-10.  新潟医学会
本文リンク: http://hdl.handle.net/10191/34992
7.

論文(リポジトリ)

論文(リポジトリ)
中澤, 俊郎 ; 武井, 伸一
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  116  pp.459-460,  2002-09.  新潟医学会
本文リンク: http://hdl.handle.net/10191/4217
8.

論文(リポジトリ)

論文(リポジトリ)
中澤, 俊郎 ; 橋本, 哲 ; 武井, 伸一 ; 矢野, 雅彦 ; 鈴木, 健太 ; 小林, 勲
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  115  pp.645-650,  2001-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/48632
概要: A retrospective review of 18 patients with liver abscesses whom we experienced in a recent 6-year period was carried out . At first these patients were divided into two groups, cystic pattern group and solid pattern group by the CT findings. Percutaneous transhepatic abscess drainage (PTAD) was performed in 5 patients of the cystic pattern group (group-A). And only systemic antibiotics therapy was done in 5 patients of the cystic pattern group (group-B), and in 8 patients of the solid pattern group (group-C). Clinical courses after treatment, temperature, CRP value and WBC counts, were compared between these three groups. The temperature, CRP value and WBC counts of group-A were improved earlier than those of other two groups. Especially the temperature of group-A was significantly lower than that of group-B at 8- and 12-day, and that of group-C at 8- and 10-day after treatment. CRP value of group-A was also significantly lower than other two groups at 1- and 2-week after treatment. The feverish period of group-A (4.2±2.4 days) was significantly shorter than that of group-C (16.8±14.2days). And the period of CRP-positive (21.2±4.3 days) and of systemic antibiotics therapy (25.2±4.3 days) of group-A were significantly shorter than those of group-B(45.6±13.1days, 43.8±14.2 days). It is concluded that PTAD is an effective technique in improving the early clinical condition in patients with liver abscesses. And PTAD can shorten the period of hospitalization and decrease the medical cost. 続きを見る
9.

論文(リポジトリ)

論文(リポジトリ)
中澤, 俊郎 ; 武井, 伸一 ; 矢野, 雅彦 ; 鈴木, 健太 ; 小林, 勲
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  115  pp.578-583,  2001-11.  新潟医学会
本文リンク: http://hdl.handle.net/10191/48497
概要: From September 1995 through December 2000, percutaneous endoscopic gastrostomy (PEG) was performed in 104 patients, aged 37 to 98 (average 77.9). PEG was successfully performed in all patients. And then 93 patients (89.4%) were discharged, and 45 patients of them were cared for at home after discharge. Four patients (3.8%) became able to take all the required diet orally, facilitating removal of PEG. Gastric perforation or panperitonitis, which can be major complication of PEG, did not occur. Fever was the most frequent (36.5%) complication in the postsurgical acute stage, and pneumonia was the next (13.5%). Bumper buried syndrome and selfremoval of tubes were occurred in three patients in the chronic stage. The survival rate of the all patients was 61.0% for 1 year and 43.4% for 2 years, respectively, and was higher than other reports. There were 7 dead cases until 30 days after PEG, and 5 patients of them were dead by pneumonia. In conclusion, PEG was a safe and useful treatment in improving quality of life of patients who were unable to swallow. But careful consideration and management were necessary for the prevention of pneumonia in the acute stage. 続きを見る