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1.

論文(リポジトリ)

論文(リポジトリ)
染矢, 俊幸
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.507-515,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46951
概要: The development of pharmacokinetics and pharmacogenetics in a last decade has been clarifying the background of remarkable interindividual variability in the metabolism of psychotropic drugs and its clinical significance. This article reviewed the followings: Interindividual variability in plasma concentration of psychotropic drugs, relationship between plasma concentration of psychotropic drugs and its clinical effect, genetic polymorphism of the enzyme which is involved in psychotropic drug metabolism, pharmacokinetic drug-drug interaction, effect of aging on pharmacokinetics, etc.. On the basis of further development of this area in psychiatry, it is desired that more rational psychiatric pharmacotherapy will be established. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
早見, 守仁
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.516-525,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46952
概要: Using a Barostat system, we have observed the volume responses to distention of ileal W pouch and evaluated the tone and visceral sensitivity in 13 patients with post-operative ulcerative colitis (mean age, 30. 3,). A Barostat system assembly was positioned anally into the ileal W pouch. We distended the ileal W pouch with the balloons by 2 mmHg increments for 2 min. applied every 1 min. and compliance of the pouch was measured. Patients declared the threshold of distending perception, threshold sense of defecation and defecating urgency. Furthermore, patients answered our formatted questions about postoperative outcome of functional scores. We concluded that 1 ) the compliance when patients declared threshold sense of defecation correlated well with the maximally tolerable volume for defecation, and it reflected the capacity of reserving stool, 2 ) the function of the ileal pouch has improved with postoperative period, and 3) the improvement of subjective functional scores were associated with compliance increase of the ileal pouch and decrease of PVEs /hour (phasic volume events/hour). 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
小川, 祐輔
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.526-536,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46953
概要: Recently, ^<123>I-β-methyl-iodophenyl pentadecanoic acid (BMIPP) has been used in myocardial scintigraphy to evaluate fa tty acid metabolism and myocardial viability. Some investigators reported absence of BMIPP-accumulation in the hearts of few patients with heart diseases. The mechanism and clinical significance of absence of BMIPP-accumulation in heart are not known. CD36, glycoprotein IV expressed in platelet membrane, is a receptor for collagen, thrombospondin, oxidised LDL and long-chain fatty acids. CD36 may play a role in platelet aggregation as well as in formation and progression of arteriosclerosis, and in myocardial fatty acid metabolism. The expression and genetic abnormality of CD36 were investigated in this study in relation to myocardial accumulation of BMIPP. There are two types of platelet CD36 deficiency; types I and II , associated with the absence and presence of CD36 on monocytes, respectively. In 200 patients with various heart diseases in this study, 24 cases revealed CD36 deficiency including 8 type I and 16 type II. No myocardial BMIPP-accumulations were observed in all 8 type I cases, while significant accumulation was seen in all type II cases. Genetic analysis of CD36 was carried in 3 of 8 cases with type I deficiency. Deletions of 52 base inn exon 4 and 70 base in exon 9 were documented in mRNA of CD36 in all 3 cases by means of sequence analysis after RT-PCR. Genomic DNA of CD36 was also analyzed by using a PCR-direct sequence method, and there were two types of point mutation, namely, ^<970>T→C/Ile-Thr (one of 3 cases) and ^<478>C→T/Pro→Ser (other 2 cases). The point mutation at ^<478>T was previously reported by other researchers. This is the first report to show the alternative splicing in exons 4 and 9 and the point mutation at ^<970> C. CD36 deficiency may contribute the pathogenesis of heart diseases and arteriosclerosis through abnormal fatty acid metabolism. 続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
島田, えり奈
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.537-537,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46954
5.

論文(リポジトリ)

論文(リポジトリ)
青海, 広之
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.537-537,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46955
6.

論文(リポジトリ)

論文(リポジトリ)
東, 敏明 ; 清水, 春夫 ; 小出, 章 ; 高橋, 祥
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.537-537,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46956
7.

論文(リポジトリ)

論文(リポジトリ)
種田, 宏司 ; 池主, 雅臣 ; 相澤, 義房 ; 福士, 智久 ; 奥村, 謙 ; 栗田, 康生 ; 小川, 聡 ; 田口, 敦史 ; 栗田, 隆志 ; 鎌倉, 史郎 ; 福島, 研吾 ; 大江, 透 ; 松崎, 益徳 ; 清水, 昭彦 ; 笠貫, 宏 ; 田中, 茂夫
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.538-538,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46957
8.

論文(リポジトリ)

論文(リポジトリ)
小林, 良太 ; 広瀬, 保夫
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.538-538,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46958
9.

論文(リポジトリ)

論文(リポジトリ)
堀, 寧 ; 藤沢, 真奈美 ; 中嶋, 真理子 ; 大関, 暢 ; 田中, 敏春 ; 木下, 秀則 ; 広瀬, 保夫 ; 本多, 拓
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.538-539,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46959
10.

論文(リポジトリ)

論文(リポジトリ)
玉谷, 真一 ; 外山, 孚 ; 佐藤, 朗 ; 伊藤, 靖
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.539-539,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46960