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1.

論文(リポジトリ)

論文(リポジトリ)
兼子, 泰行
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  105  pp.177-186,  1991-03.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38651
概要: To investigate alterations in the basement membrane (BM) and of fibronectin receptor (FNR) in malignant melanoma (MM), t he tumor were studied immunohistochemically by double immunofluorescent staining using monoclonal antibodies to the core protein of heparan sulfate proteoglycan(HSPG), collagen type III(C-3)and chondroitin 6-sulfate (C6S) as well as antiserum to laminin, collagen type IV (C-4), fibronectin and fibronectin receptor. In MM in situ, C-4, laminin and HSPG were preserved as a continuous linear band on the dermo-epidermal junction (DEJ), while C6S is extensively lost from the DEJ and fibronectin is remarkably decreased in the papillary dermis compared with the normal skin. In invasive, MM, although the distribution pattern was varied case by case, the BM components were not decreased. The cases were divided into two groups by the distribution pattern; a great amount of each BM component were localized on the surface of tumor cells, or surrounded tumor nests, forming the large nests. In all but one cases examined, however, C6S was absent from the BM zone of the melanoma nests in the dermis. These data indicates that although C6S was absent, the other BM components were actively synthesized by tumor cells, and that the BM components were altered in phase of MM in situ. Intensity of FNR of melanoma cells were generally more fainter than those of infiltrating lymphocytes in the dermis, basal cells of the epidermis and endothelial cells of small vessels. There were no significant differences in their intensity of melanoma cells between each tumor progression phase. Therefore, the present study may reveal that these receptors do not relate to invasion or metastasis of the tumor. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
児玉, 省二 ; 吉谷, 徳夫 ; 遠間, 浩 ; 中村, 稔 ; 田中, 憲一
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.394-398,  1993-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37390
概要: We retrospectively analyzed clinicopathological review of 4 patients with primary malignant melanoma of the female genital tract. Of these patients, two had cervical lesion, one had vaginal lesion and one had vulvar lesion. The age of 4 patients were 33, 41, 82 and 84-year-old. One patients with cervical lesion treated with only chemotherapy because of advanced stage (stage IV disease with lung metastasis). Of the 3 patients treated by surgery and lymph nod dissection, 2 had nodes involved by tumor. In the histologic classification of melanoma, 3 patients had mucosal melanoma and one patient had acral lentiginous melanoma. All patients had advanced tumours and depth of invasion was greater than 8mm in 3 cases treated by surgery. Various chemotherapeutic regimens, PAV, DAV and PVB, were employed. Three patients died of disease within 15months after diagnosis. One patient treated with chemotherapy died of pneumonitis, with disease, at 4months. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
五十嵐, 文雄
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.399-403,  1993-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37392
概要: A clinical study was conducted on 16 patients with malignant melanoma who were registered between 1986 and 1990 by the registration committee for malignant head and neck tumors of Niigata prefecture. Ten tumors originated in the nasal cavity, 3 in the cervical skin, 2 in the paranasal sinus, and 1 in the lower gingival mucosa. The mean age of patients was 64.8years, and 10 were men and 6 were women. The inital symptom of tumors originating in the nasal cavity or paranasal sinus was epistaxis or nasal obstruction, whereas that of tumors originating in the cervical skin or the lower gingival mucosa was tumor formation. The mean duration from the appearance of the initial symptom to consultation was 5.0 months, that of tumors originating in the mucosa was 3.8 months, and that of tumors in the skin was 10.0 months. The mean duration was significantly shorter in mucosal tumors than in cutaneous ones. The most common local findings were black or black-brown tumor, black or black-brown pigmentation, or both. However, in 4 nasal and paranasal tumors, dark-red or grey-white tumor that resembled nasal polyp was recognized. Radical treatment was performed in 14 cases, and palliative treatment in 2. In radically treated cases, surgery was the main therapy, and chemotherapy or radiotherapy ware used adjuncts. Palliative treatment consisted of radiotherapy or injection of interferon. At this time, 6 patients are tumor free, 3 are alive with tumor, and 7 have died. As the major cause of death was distant metastasis, more effective general therapy is needed. 続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
小山, 真 ; 榎本, 一彦 ; 阿部, 僚一
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.412-419,  1993-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37398
概要: Four patients with advanced melanoma had been treated with the amino acid imbalance therapy using the Phenylalanine-Tyrosin deprived milk by the authors at the surgical unit of Sanjo Saiseikai Hospital and Niigata prefectural Yoshida Hospital within past 15 years. In three of four patients, the therapy showed the remarkable effects. The reduction of the ulcerating melanomas in patient 1 and 2 or the disappearance of the recurrent melanoma of the colon of patient 3 were observed within 1 to 4 weeks after the start of the therapy. In patient 4, who had too extensive dissemination of the melanoma, the therapy could not show the effect. As a result, patient 1. whose melanoma became resectable by the therapy and patient 3, whose recurrent melanoma of the colon was disappeared by the therapy could survive for a long time of 16 and 6 years respectively withont any sign of recurrence of melanoma. But, patient 2, who could not tolerate the therapy, and patient 4 died of melanona at 12 and 2 months after the therapy. Thus, the authors would like to stress the importance of further studies to confirm a possible validity of the Phenylalanine-Tyrosin deprived amino acid imbalance therapy for the treatment of patients with melanoma, because the therapy revealed the appreciable effects on the advanced melanomas of three of four patients to whom chemoimmunotherapy was uneffective by the authors' clinical experiences. 続きを見る