残胃癌の粘膜組織化学的検討

フォーマット:

論文(リポジトリ)

責任表示:

山中, 秀夫

出版情報:

新潟医学会, 1992-02

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

山中, 秀夫  

巻:

106

通号:

2

開始ページ:

76

終了ページ:

88

概要:

In order to clarify the histogenesis and mucin-character of carcinomas in the remnant stomach, 47 tumors (23 early and 24 advanced carcinomas) were selected, which occurred 10 years or more after the first gastrectomy. The results are as follows : (1) 92% of the tumors was a mixed type with gastric and intestinal mucin. (2) The differentiated type carcinoma was composed of tumors with predominantly gastric mucin (23% in the early and 18% in the advanced … carcinoma), and tumors with predominantly intestinal mucin (77% in the early and 82% in the advanced carcinoma). (3) While, the undifferentiated type carcinoma consisted of tumors with predominantly gastric mucin (100% in the early and 31% in the advanced carcinoma), and tumors with predominantly intestinal type (61% only in the advanced), and a tumor with intestinal mucin (8% only in the advanced). (4) In the mucosa, many of the carcinomas showed a three-layered pattern like the normal gastric mucosa, the upper layer with GOS-positive, the middle layer without mucin, and lowest layer with ConA-III positive cells, but the layer-archetecture was lost in the invasive area. (5) Four of 10 carcinomas less than 10mm occurred in the anastomotic site, and three of them were surrounded by fundic mucosa (two with stomal gastritis) and one by moderately intestinalized mucosa. While, the remaining six occurred in the non-anastomotic site, and three of them developed in the fundic mucosa, and three in the intestinalized mucosa. (6) The carcinoma of the anastomotic site showed a milder intestinal metaplasia than non-anastomotic carcinoma. It is concluded that many of the carcinomas in the remnant stomach have gastric mucin character, but it disappears in the invasive area, especially of the differentiated carcinoma, and that there are two kinds of gastric mucosa for the histogenesis of carcinoma in the remnant stomach, fundic mucosa (or modified fundic mucosa=stomal gastriris without intestinal metaplasia), and intestinalized mucosa. 続きを見る

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