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論文(リポジトリ)

論文(リポジトリ)
早見, 守仁
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  113  pp.516-525,  1999-12.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46952
概要: Using a Barostat system, we have observed the volume responses to distention of ileal W pouch and evaluated the tone and visceral sensitivity in 13 patients with post-operative ulcerative colitis (mean age, 30. 3,). A Barostat system assembly was positioned anally into the ileal W pouch. We distended the ileal W pouch with the balloons by 2 mmHg increments for 2 min. applied every 1 min. and compliance of the pouch was measured. Patients declared the threshold of distending perception, threshold sense of defecation and defecating urgency. Furthermore, patients answered our formatted questions about postoperative outcome of functional scores. We concluded that 1 ) the compliance when patients declared threshold sense of defecation correlated well with the maximally tolerable volume for defecation, and it reflected the capacity of reserving stool, 2 ) the function of the ileal pouch has improved with postoperative period, and 3) the improvement of subjective functional scores were associated with compliance increase of the ileal pouch and decrease of PVEs /hour (phasic volume events/hour). 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
丸田, 智章 ; 畠山, 勝義 ; 本間, 信治
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  111  pp.34-46,  1997-01.  新潟医学会
本文リンク: http://hdl.handle.net/10191/44416
概要: Ileal pouch anal anastomosis(IPAA)has relieved many patients of Ulcerative colitis and familial adenomatous polyposis co li from their many complaints and made enabled them to defecate transanaly. However, some patients who underwent IPAA still have poorly functioning pouches and they suffer from new complaints such as frequent defecation, incontinence and so on. Therefore, functional assessment seems necessary for the ileal W pouch. We measured the compliance and motility of the ileal W pouch. In addition, the electrical activities from the parasacral skin were recorded, if they reflect the motility of the ileal W pouch. These indices were correlated to clinical scores, if they reflect the clinical status. Chord compliance when the subject had the initial or first sensation to evacuate was correlated well with the maximal volume of the ileal W pouch, or with the “permitted volume”(the volume the subject could not tolerate any more to evacuate, minus the minimum volume when the subject had the initial or 1st feeling to defecate). The spectral frequency of the phasic intraluminal wave of the ileal W pouch decreased as the postoperative duration. The clinical score increased as the spectral frequency of the pouch wave decreased. This probably indicates the improved function of the ileal pouch. The motility ileal pouch seemed to be reflected, in some cases, by the electrograph by surface electrodes. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
唐木田, 丈夫
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  103  pp.520-532,  1989-06.  新潟医学会
本文リンク: http://hdl.handle.net/10191/41297
概要: In order to elucidate the physiological mechanisms of diabetic gastrointestinal disorders, isolated gastrointestinal segments of streptozotocin diabetic rats were studied in vitro from the following viewpoint, i. e. , the size, motor activities, passive physical properties, drug-induced contractility and transmitter contents. 1) Diabetic rats had longer small and large intestine than normal. Wet weight of the diabetic duodenum, jejunum, ileum, colon and caecumu was heavier than that of normal. Stomach weight was similar between diabetic and normal rats. 2) Motor activities were examined by recording the changes in frequency and amplitude of spontaneous intraluminal pressure of isolated preparations, as well as those in electromyographs with suction electrodes. Frequency of the diabetic upper intestine, especially of the duodenum, was significantly lower than that of normal. Amplitude of intraluminal pressure in the diabetic jejunum and caecum was smaller than that of normal. These results suggested the pacemaker disorders in diabetic preparations. 3) Acetylcholine and substance P induced-contractility of the diabetc duodenum, jejunum and ileum was smaller than that of normal, both in longitudinal and circular muscle preparations. However, colonic responsibility to acetylcholine and substance P was similar between diabetic and normal preparations. 4) Substance P and somatostatin contents in gastrointestinal tract were determined by radioimmunoassay. Substance P and somatostatin content per wet weight was increased in the diabetic corpus of stomach. Substance P was decreased in the ileum and caecum and somatostatin was decreased in the caecum. 5) Passive mechanical properties were compared by recording pressure-volume relationships of the isolated gastrointestinal tracts by infusing Tyrode's solution into them. Maximal volume infused was larger in diabetic than in normal preparations even after corrected for length and wet weight. Therefore, compliance or distensibility was higher in diabetic than in normal preparations. In conclusion, disorders of diabetic gastrointestinal tract were suggested to be due to pacemaker disorders, higher compliance, decreased drug-responsibility and transmitter content. 続きを見る