1.
論文(リポジトリ) |
渡部, 久実 ; 宮路, 智香子 ; 宮川, 亮子 ; 安保, 徹 ; 佐藤, 好信 ; 山本, 智 ; 飯合, 恒夫 ; 黒崎, 功 ; 白井, 良夫 ; 畠山, 勝義 ; 市田, 隆文 ; 野本, 実 ; 土屋, 淳紀 ; 石本, 結子 ; 朝倉, 均
|
|||||
2.
論文(リポジトリ) |
富山, 智香子 ; 石本, 結子 ; 塚田, 知香 ; 横山, 恒 ; 宮川, 亮子 ; 菅原, 聡 ; 山際, 諭 ; 楊, 秀華 ; 渡部, 久実 ; 佐藤, 好信 ; 市田, 隆文 ; 安保, 徹 ; 朝倉, 均
|
|||||
3.
論文(リポジトリ) |
陳, 煒 ; 柴田, 実 ; 張, 晶 ; 冉, 維志 ; 小坂, 健之 ; 久保田, 茂夫 ; 渡部, 久実
概要:
Allo-tissue or-organ such as skin or joint transfer requires to induct an efficient immunological suppression with less
…
side effects than those of the present vital organ transfer. We conducted allo-skin grafting using rats with major histocompatibility mismatching. A full thickness abdominal skin of the Lewis rat, 1.5×2.0 cm in size, was harvested and grafted on to the back of Brown Norway rat. We inducted immunological tolerance using daily injection of 2 mg/kg anti-CD 2 monoclonal antibodies to the recipient BN rat starting from one day before surgery until 7 days postoperation except the day of the surgery. We also treated the immunogenecity of the grafting donor skin with cryopreservation. The donor skin grafts were soaked in 1.4 mol glycerol solution for tissue protection and frozen in step wise using programming freezer and then preserved in liquid nitrogen tank for 21 days before grafting. The results were evaluated by the close observation of the grafted skin condition, and the immunological conditions were assessed by flow cytometry and mixed lymphocyte reaction (MLR) test. The grafted cryopreserved skin was rejected 17 days postoperatively in average in anti-CD 2 MoAb administrated rats and 14 days in rats without anti-CD 2 MoAb administration. There was no hair regrowth in the skin grafted area which underwent rejection and re-epithelialization suggesting the presence of the dermis of the grafted skin in half of the rats treated with cryopreservation, and only one in rats without cryopreservation 4 months postoperatively. Flow cytometry and MLR test suggested that immunological tolerance was partly established. These results suggests that combined treatment of the recipient using anti-CD 2 MoAb and that of donor by cryopreservation may establish an effective immunological tolerance in allo-skin grafting.
続きを見る
|
|||||
4.
論文(リポジトリ) |
亀山, 仁史 ; 川村, 俊彦 ; 内藤, 哲也 ; 坂内, 誠 ; 渡部, 久実 ; 安保, 徹
|
|||||
5.
論文(リポジトリ) |
橋立, 英樹 ; 渡辺, 英伸 ; 味岡, 洋一 ; 西倉, 健 ; 安保, 徹 ; 渡部, 久実 ; 宮川, 亮子 ; 内藤, 哲也 ; 菅原, 聡 ; 良田, 裕平 ; 相場, 恒男
|
|||||
6.
論文(リポジトリ) |
渡部, 久実
|
|||||
7.
論文(リポジトリ) |
齋藤, 玲子 ; 渡部, 久実 ; Win, Su Mon Kyaw ; Win, Nay Chi ; Ja, Lasham Di ; 齋藤, 昭彦
概要:
2017年,ミャンマーでインフルエンザA/H1Nlpdm09の大流行が起こった.肺炎による死者が続き一時はパニックに陥った.新潟大学は,ミャンマー国立衛生研究所と協力して流行制圧に貢献した. ウイルス遺伝子解析の結果から重症者化を起こすウイ
…
ルス変異は認められないこと,ミャンマー株はインドから伝播し,2018 年の冬にはこの株が日本で流行したことを突き止めた.
続きを見る
|