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1.

図書

図書
渡部久実研究代表
出版情報: [新潟] : [渡部久実], 1999.3
シリーズ名: 科学研究費補助金基盤研究(C)(2)研究成果報告書 ; 平成9-10年度
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2.

論文(リポジトリ)

論文(リポジトリ)
渡部, 久実
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  112  pp.667-670,  1998-11.  新潟医学会
本文リンク: http://hdl.handle.net/10191/46332
概要: Many functions of cells of the immune system are mediated through the production of cytokines. CD4+ helper T cells diffe rentiate functionally into one of two subsets, Th1 or Th2. Th1 cells generate IL-2 and IFNγ and support the cellular immune responses. On the other hand, Th2 cells generate IL-4, IL-5 and IL-10 and support the humoral immune responses. A unique population of T cells that carry intermediate levels of TCR exist in the liver and other immune organs. These T cells express IL-2Rβ-chain and receptors of the NK cell lineage. Many investigators call them intTCR cells or NKT cells. Recently, it was demonstrated that NKT cells produce IL-4 and IFN-γ and regulate the differentiation of CD4^+ helper T cells into Th1 or Th2 cells. These findings indicate that NKT cells play an important role of immune regulation by cytokines. 続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
久保田, 茂夫 ; 柴田, 実 ; 山村, 倉一郎 ; 三輪, 仁 ; 松崎, 浩徳 ; 生沼, 武男 ; 渡部, 久実
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  111  pp.476-477,  1997-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/45173
4.

論文(リポジトリ)

論文(リポジトリ)
渡部, 久実 ; 飯合, 恒夫 ; 安保, 徹
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.425-429,  1993-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37391
概要: Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity. 続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
渡部, 久実 ; 河又, 聡子
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  100  pp.310-316,  1986-06.  新潟医学会
本文リンク: http://hdl.handle.net/10191/34856
6.

論文(リポジトリ)

論文(リポジトリ)
渡部, 久実 ; 藤原, 道夫
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  103  pp.350-353,  1989-05.  新潟医学会
本文リンク: http://hdl.handle.net/10191/41251
概要: Interleukin 1 (IL-1) is normally produced by activated MΦ and has a wide range of biological activities. One of these ac tivity is the capacity to induce the IL-2 production of T cells. Interleukin 2 (IL-2), produced by activated T cells, induces the proliferation and differentiation on T and B cells. In this report, the signal requirement for the activation of T cells in C57BL/6 mice was examined in in vitro responses to mutant MHC class I antigen (H-2K^<bm1>). From our observations, activation of T cells responding to MHC class I antigen could be explained as follows. Lyt 2^+ T cells recognize directly the mutant MHC class I antigen and then IL-1 receptor (IL-1R) and IL-2 receptor (IL-2R) appear on the T cells. Accessory cells secrete IL-1 upon the binding of T cells. The secreted IL-1 may bind IL-1R on the responding T cells and induce production of IL-2, which binds to IL-2R. Thus, T cell proliferation and CTL (cytotoxic T lymphocyte) generation will proceed autonomously. 続きを見る
7.

論文(リポジトリ)

論文(リポジトリ)
小川, 充 ; 飯合, 恒夫 ; 渡部, 久実 ; 安保, 徹
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  107  pp.772-772,  1993-08.  新潟医学会
本文リンク: http://hdl.handle.net/10191/37616