8) 悪性黒色腫とその前癌症 : 最新治療概念と今後の展望(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)

フォーマット:

論文(リポジトリ)

責任表示:

三嶋, 豊

出版情報:

新潟医学会, 1993-05

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

三嶋, 豊  

巻:

107

通号:

5

開始ページ:

430

終了ページ:

437

概要:

Progression of human melanomas occurs by focal and multi-step oncogenesis from normal pigment cells. Accentuated melanosome-genesis accompanies this process through precancerous stages to malignant melanoma along with possible genetic alterations, which should be more fully explored for better melanoma control. Refined criteria based on new molecular to clinical analyses of lesion behavior, need to be made for each step of melanoma progression. Melanoma progression is … found to be associated with a variety of structural and biochemical changes in cell surface and in cytoplasmic molecular properties, e.g. membrane carbohydrate and antigen expression dynamics, pheomelanogenesis, oncogene including suppressor gene expression, chromosome abnormalities and A^X actin synthesis. Based on these basic and clinical findings, our scheme on melanoma oncogenesis (see Table 1. in the attached Japanese section of this paper) has been elucidated. 続きを見る

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