7) メラノーマと胸腺外分化T細胞(シンポジウム 悪性黒色腫の現況と治療, 第477回新潟医学会)

フォーマット:

論文(リポジトリ)

責任表示:

渡部, 久実 ; 飯合, 恒夫 ; 安保, 徹

出版情報:

新潟医学会, 1993-05

掲載情報:

新潟医学会雑誌 — 新潟医学会雑誌

ISSN:

00290440      

著者名:

• 渡部, 久実
• 飯合, 恒夫
• 安保, 徹

巻:

107

通号:

5

開始ページ:

425

終了ページ:

429

概要:

Extrathymic T cells in mouse liver have TCR of intermediate intensity, contain doublenegative CD4^-CD8^- cells, and comprise forbidden self-reactive oligoclones. In the present study, we investigated how such extrathymic T cells were modulated during melanoma development in melanoma transgenic mice. Melanoma appeared in various organ of the transgenic mice at 15 wk of age. Extrathymic T cells with TCR of intermediate intensity increased in the liver, as the tumors … advanced. Such cells infiltated the tumor lesions. In consequence of this study, it was proved that extrathymic T cells in the liver played important roles in tumor immunity. 続きを見る

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