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4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)

フォーマット:
論文(リポジトリ)
責任表示:
望月, 博史 ; 光山, 正雄
出版情報:
新潟医学会, 1998-11
掲載情報:
新潟医学会雑誌 = 新潟医学会雑誌
ISSN:
00290440  CiNii Research  Webcat Plus  JAIRO
著者名:
巻:
112
通号:
11
開始ページ:
680
終了ページ:
684
バージョン:
publisher
概要:
Propionibacterium acnes has been implicated as the etiologic agent of sarcoidosis since the isolation of this bacterium at a high incidence from sarcoidosis specimens in 1978. However, this possibility has not been established or accepted w idely yet. We have obtained the P. acnes strains isolated in that study. Based on the idea that inflammatory cytokines are involved in granuloma formation characteristic for pathology of sarcoidosis, we have compared the cytokine-inducing ability among various strains. [Method] Peripheral blood mononuclear cells were obtained from sarcoidosis patients and healthy controls. Cells were stimulated with P. acnes strains in vitro, and inflammatory cytokines were determined by using cytokine-specific EIA. The effect of T-cell depletion was examined. [Result] Th1-type of antigen-specific response was not observed when patient cells were stimulated with P. acnes. Strains from sarcoidosis specimen showed a significantly higher activity for induction of IL-12 and IFN-γ for whole mononuclear cells and also for T cell-depleted population. [Conclusion] The results suggested that particular P. acnes strains capable of inducing a high level of inflammatory cytokine are involved in the pathogenesis of sarcoidosis. It was postulated that P. acnes first stimulate macrophages to produce IL-12 then in turn stimulate NK cells to produce IFN-γ which may contribute to granuloma formation. 続きを見る
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