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2)胸腺外分化T細胞の分化とサイトカイン(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)

フォーマット:
論文(リポジトリ)
責任表示:
宮路, 智香子
出版情報:
新潟医学会, 1998-11
掲載情報:
新潟医学会雑誌 = 新潟医学会雑誌
ISSN:
00290440  CiNii Research  Webcat Plus  JAIRO
著者名:
宮路, 智香子  
巻:
112
通号:
11
開始ページ:
671
終了ページ:
675
バージョン:
publisher
概要:
Recent studies demonstrated that murine liver contained extrathymically differentiated T cells. These cells express intermediate (int) level of TCR (CD3) and IL-2Rβ chain. However, it has been unknown about the development of these int TCR cells without requirement of thymus. Here, we investigated how the int TCR cells were differentiated and proliferated. The int TCR cells but not the other peripheral T cells responded to exogenous IL-7 which supported TCR cell differentiation in thymus. Similar to the bone marrow (BM), the liver contained hematopoietic stem cells (c-kit^+Lin^-) which enabled to reconstitute T, B, macrophage and myeloid cells in irradiated SCID mice. In vitro, the hematopoietic stem cells in the liver did not differentiate into the int TCR cells either in the presence of fetal thymus or thymic stromal cells. However liver-derived stromal cells which could produce IL-7 and other cytokines, supported int TCR cell differentiation. On the other hand, those in BM did not develop the int TCR cells in any condition. Taken together, the int TCR cells in the liver are supposed to be developed in situ from the hematopoietic stem cells in the liver in association with some cytokines like IL-7. 続きを見る
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