6) アレルギー性脳脊髄炎(シンポジウム 自己免疫疾患, 第445回新潟医学会)

フォーマット:

論文(リポジトリ)

責任表示:

松本, 陽

出版情報:

新潟医学会, 1989-12

掲載情報:

新潟医学会雑誌 = 新潟医学会雑誌

ISSN:

00290440      

著者名:

松本, 陽  

巻:

103

通号:

12

開始ページ:

985

終了ページ:

987

バージョン:

publisher

概要:

Experimental allergic encephalomyelitis (EAE) is a T-cell mediated autoimmune disease inducible by immunization with brain specific antigens such as myelin basic protein (MBP) in complete Freund's adjuvant (CFA). Using EAE as an experimental model for human autoimmune disorders, we show here several experimental approaches and the results obtained by these approaches. They include 1) immunohistochemical examination of the lesions of EAE, 2) double … immunofluorescent staining of the tissue in order to identify the nature of cells of interest, 3) passive EAE which facilitutes the examination of developing lesions of EAE, and 4) radiation bone marrow chimeras which were prepared for the detection of bone marrow-derived cells in the central nervous system. We also introduced limiting dilution analysis of MBP-reactive T cells and thymus-grafted chimeras. 続きを見る

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