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抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して

フォーマット:
論文(リポジトリ)
責任表示:
本間, 照
出版情報:
新潟医学会, 1992-02
掲載情報:
新潟医学会雑誌 = 新潟医学会雑誌
ISSN:
00290440  CiNii Research  Webcat Plus  JAIRO
著者名:
本間, 照  
巻:
106
通号:
2
開始ページ:
89
終了ページ:
97
バージョン:
publisher
概要:
Immunohistological study by a monoclonal antibody against DNA polymerase α was made for the investigation of labeling index (LI) and proliferative zone in normal mucosa and tumors (-like lesions) of the colon and rectum (normal mucosa ; n=9, hyperplastic polyps ; n=6, tubular adenomas ; n=30 and intramucosal carcinomas ; n=3). The normal mucosa and hyperplastic polyps showed a similar distribution of proliferating cells, forming a proliferative zone which restricted to the lower portion of the crypt (up to about 200μm from the glandular base). In adenomas, the distribution of proliferating cells differed by size ; small tubular adenomas, 5mm or less in size, had proliferative zone in the upper portion of neoplastic tubules (down to 200~400μm from the surface), oppositely to that of the non-neoplastic mucosa. While tubular adenomas more than 5mm showed even distribution of proliferative cells along the whole length of the tubules. In all three mucosal carcinomas, the distribution pattern was similar to that of the latter-group adenomas. The LIs was not significantly different between the proliferative zone of normal mucosa (60.8±6.6), and that of adenomas (small ; 64.6±1.6, larger ; 62.5±5.6). But in carcinomas, it was significantly higher (77.8±0.7). The formation of proliferative zone in small adenomas like non-neoplastic mucosa (but opposite location), suggests that they have a lower potential of proliferation. But the different distribution-patterns of proliferating cells in the larger adenomas indicates that the proliferating activity changes as adenomas grow. 続きを見る
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高村, 麻子

新潟医学会

高村, 麻子

高村, 麻子

新潟大学大学院医歯学総合研究科