胸腺外分化T細胞の性差とアンドロゲンによる制御

フォーマット:

論文(リポジトリ)

責任表示:

木村, 元彦

出版情報:

新潟医学会, 1994-03

掲載情報:

新潟医学会雑誌 = 新潟医学会雑誌

ISSN:

00290440      

著者名:

木村, 元彦  

巻:

108

通号:

3

開始ページ:

200

終了ページ:

211

バージョン:

publisher

概要:

Male predominance of malignant disease and female predominance of autoimmune disease are widely known in humans. To elucidate one of the underlying mechanisms, we examined whether sex differences exist at the level of extrathymic T cells in various organs of mice under physiological conditions. Effects of orchiectomy or testosterone administration were also examined. Extrathymic T cells expressing CD3 of intermediate intensity (i. e., … intermediate TCR cells) and a high level of IL-2 receptor β-chain (IL-2Rβ), and thymusderived T cells expressing of TCR of bright intensity (i. e., bright TCR cells) and lacking IL-2Rβ, were identified by immunofluorescent tests. Of each three strain tested, it was demonstrated that intermediate TCR cells were much more predominant in the liver and some other organs in female mice than in male mice. In the liver of orchiectomied mice, the number of mononuclear cells increasod and intermediate TCR cells became predominant as if the mice were female. Testosterone replacement canceled the immunological effect of orchiectomy. Considering the fact that extrathymic T cells comprise a considerable proportion of self-reactive forbidden clones and possess cytotoxic activity aganinst syngenic tumor cells, the present results might suggest a possible relationship between physiologically low levels of extrathymic T cells and the male predominance of malignancy. 続きを見る

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