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論文(リポジトリ)

論文(リポジトリ)
林, 純一 ; 小熊, 文昭 ; 中沢, 聡 ; 江口, 昭治 ; 丸山, 行夫 ; 山添, 優 ; 和泉, 徹 ; 柴田, 昭 ; 服部, 晃
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  108  pp.527-531,  1994-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38357
概要: In order to clarify the benefit of treatment using ticlopidine with low-dose aspirin on saphenous vein graft patency after aorto-coronary bypass, a randomized study was performed on 135 patients who were operated between January 1987 and March 1991 at Niigata University Hospital or Niigata Kobari Hospital. Among them, 38 patients were excluded from the study because they didn't meet the protocol requirements. Subjects were divided into antiplatelet therapy (AT) group (n=58) and control group (n=39). Saphenous vein graft patency was evaluated by coronary angiography 1 month after the operation. Although the overall graft patency rate was 86.5% in the AT group and 81.4% in the control group (N.S.), higher patency rate were noticed in the AT group than those in the control group in grafts on the left anterior decending and the right coronary arteries. The present study suggest that the antiplatelet treatment will play a favorable role on maintaining the graft patency. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
藤田, 俊夫 ; 相沢, 正樹 ; 山添, 優 ; 和泉, 徹 ; 柴田, 昭 ; 服部, 晃 ; 林, 純一 ; 江口, 昭治
出版情報: 新潟医学会雑誌 — 新潟医学会雑誌.  108  pp.532-539,  1994-07.  新潟医学会
本文リンク: http://hdl.handle.net/10191/38360
概要: The present study was aimed to elucidate the effect of antiplatelet therapy on patency of saphenous vein graft after aor to-coronary bypass surgery. We divided the 96 patients who underwent aorto-coronary bypass surgery into two groups: GATS (Graft Aspirin Ticlopidine Study) group and control group. And the occlusion rate was assessed both at the time of one month and 12 months after bypass surgery. All patients received warfarin, and the patients in GATS group received aspirin (10~50mg) and ticlopidine (100~200mg). The patients in control group received only warfarin. In GATS group, the early occlusion rate was 14.6% and the late occlusion rate was 28.8%. On the other hand, the early occlusion rate was 19.2% and the late occlusion rate was 28.8% in control group. There was no significant difference in the occlusion rate between GATS group and control group. In patients whose graft flow was under 50ml/min, the occlusion rate in GATS group was 10.8%, but in control group was 32.1% at the time of one month. These results indicate that antiplatelet therapy after A-C bypass surgery may have no effect on whole occlusion rate, but may have a little effect on the occlusion rate in low graft flow group. It may be important that when we should start the antiplatelet therapy after aortocoronary bypass surgery. 続きを見る