close
1.

論文(リポジトリ)

論文(リポジトリ)
大桃, 幸夫
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  103  pp.644-651,  1989-08.  新潟医学会
本文リンク: http://hdl.handle.net/10191/41373
概要: Efficacy and rationale of our scheduled protocol were studied, as to a measure for prevention of vertical HBvirus transmission to the babies. We examined on 70 babies whose mother were positive for HBsAg and HBeAg. The protocol was administration of HB-immunoglobulin (HBIG) within 48 hours after birth when the umbilical cord serum was negative for HBsAg, followed by vaccination with inactivated HB-virus for three times at 2 months, 3 months and 5 months after birth. The results obtained are as follows; 1. Three cases out of 70 became HB-carriers by 2 months after birth, although HBIG was administerd to the cases. Out of remaining 67 cases treated as scheduled, one became HB-carrier at 1 year old and another one case became transiently positive for HBsAg at 7 months after birth. Sixty-five cases out of the 70 babies (92.9%) were thus successfully prevented from being HB-carrier. 2. In these 65 cases, times of the vaccination necessary for acquiring active immunity were analyzed. Fifty-four cases out of 65 infants (85.1%) gained sufficient anti-HBsAb titer (titer of 2^2) by 2 to 3 times of vaccination, and 9 cases (13.8%) by 4 times of vaccination. Two cases (4.6%), however, rembined to be negative for HBsAb even after 4 times of vaccination. 3. The titer of serum anti-HBsAb was serially examined by passive hemagglutinin (PHA) method in 46 cases who have been followed up for more than 12 months after birth. In more than 50% of the cases who had produced sufficient anti-HBs at 6th or 8th month, significantly high titer of anti-HBs was found to persist 24th month after the birth. 4. The mean value of anti-HBs antibody titer at 6th or 8th month after birth was 2^<3.6> and the half life of anti HBs-titer in the babies was estimated to be 12.65 month. These data strongly suggested that the protocol adopted in this study was an effective and rational one for preventing the vertical transmission of HB-virus from mothers positive for HBeAg to the babies. It was also confirmed that the amount of anti-HBs antibody produced under this protocol regimen persisted at least as long as the 24th month after birth. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
薗部, 友良
出版情報: 新潟医学会雑誌 = 新潟医学会雑誌.  128  pp.411-415,  2014-09.  新潟医学会
本文リンク: http://hdl.handle.net/10191/43891
概要: 2013年4月にヒブ, 小児用肺炎球菌, HPV (ヒトパピローマウイルス)ワクチンは, 定期接種になった. 残されたワクチンの中で, 水痘, ムンプス(流行性耳下腺炎), B型肝炎は来年度以降定期接種化される見込みだが予断を許さない. 今 回この大切な3ワクチンの必要性につき, 簡単に記す. 共通する点はこの3ワクチンで防げる疾患(Vaccine Preventable Diseases)は, 一般の方はもとより, 医療従事者にも知られていない多くの重い合併症があることと, 良い予防ワクチンが存在することである. ムンプスに関しては, 脳炎, 難聴などの合併症が多い. 水痘も, 水疱部位からの重症細菌感染症, 神経合併症, 肺炎などが多く, 死亡者も毎年20名, 入院患者も2千人以上存在する. B型肝炎は, 毎年1-2万人が感染する重大な疾患である. 多くは不顕性感染であるがそれでも将来デノボ肝炎を起こす危険性はある. 発症すると, 年齢が低いほど慢性肝炎に移行し, その一部が肝硬変, 肝がんになる. 現在成人領域でも, 慢性肝炎のみならず, 遺伝子型AのB型肝炎感染症の流行, デノボ肝炎, 輸血後肝炎の問題も大きい. これらは, 母子感染対策では流行の制御はできず, 世界標準の子ども全員へのユニバーサル接種が大切である. 各疾患のワクチンに関しては, 疾患特性から接種時期が決められ, 流行性耳下腺炎と水痘では2回接種, B型肝炎は3回接種が必要である. 当然, 定期接種化しないことには接種率は上がらず, 日本の未来である子どもたちの予防可能な被害が続くことになる. 続きを見る