1.
論文(リポジトリ) |
杉山, 一教 ; 富所, 隆
概要:
Therapy of gastric and duodenal ulcers has achieved a striking progress of the appearance of muscarin receptor antagonist (pirenzepine) and histamine H_2-receptor antagonist (H_2-blocker). Especially disappearance of subjective
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symptoms and promotion of cure achieved by these drugs are widely well-appreciated. On the other hand, with the acumulation of use experience of the drugs, much attention is being paid to the importance of early recurrence and maintenance therapy. At this point, attention is newly focused on the reevaluation of conventional enhancers of defensive factors. The authors describe the current status of therapy of peptic ulcers mainly based on our experience.
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2.
論文(リポジトリ) |
渡辺, 裕 ; 村山, 久夫
概要:
The cure rate for endoscopic therapy was determined in 61 patients with a gastroduodenal ulcer who received Ranitidine at a dose of 150 mg twice daily, in the morning and evening. The ulcer patients were classified into initial-,
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recurrent-and intractable-ulcer groups, and the cumulative cure rate was compared among the three types of ulcers. The cure rate was 93% for the initial ulcer, 78% for recurrent and 50% for intractable. Uncured ulcers accounted for about 10% of the patients, and the rate of uncured ulcers was particularly high among duodenal ulcer patients. The patients' background factors such as smoking or nonsmoking, seasonal variation, and blood type were also compared among the three groups of patients. Specific endoscopic findings which were studied after use of an H_2-blocker were characterized by an elevation of the mucous membrane around the ulcer. The effects of H_2-blocker dosage reduction and discontinuation on gastroduodenal were determined. Given the fact that all patients relapsed after discontinuation of the H_2-blocker, ulcers seem to indicate maintenance H_2-blocker therapy, and smoking patients, among others, appear to be in need of lifetime therapy. When using an H_2-blocker, its indication should be clearly determined, and therapy should be instituted in due consideration of an ulcer as a psychosomatic disorder.
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