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田川宏 [ほか著]
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| 2.
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図書
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伊藤文雄著
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伊藤文雄著
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河田光博, 稲瀬正彦著
目次情報:
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伊藤文雄 [著] ; 河上敬介選
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伊藤文雄著
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伊藤文雄 [著] ; 辻井洋一郎選
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| 8.
論文(リポジトリ) |
論文(リポジトリ)
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成澤, 弘子
概要:
Morphological changes of proximal segment of severed rats' sciatic nerves at different time lapses after its severance at the sciatic notch together with difference in morphological changes between motor (anterior root) and sensory
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(posterior root) fibers were investigated with the following method and following results were obtained. [METHOD] Left sciatic nerve of twenty five rats was severed and ligated at the proximal portion of the sciatic notch. At two weeks, one month, two months, three months and six months after the severance, bilateral sciatic nerves were harvested from the severed level to the anterior and posterior root level. Morphological changes were investigated at three levels, i. e. 15-20 mm proximal to the severed level (level 1), just distal to the posterior root ganglion (level 2) and just proximal to the posterior root ganglion (level 3). Level 1 comprises motor and sensory fibers, level 2 and 3 comprise separate motor nerve fiber (anterior root) area and sensory nerve fiber (posterior root) area. With the particle size analizer, histogram of fiber diameters was made and mean diameter was calculated. [RESULTS] 1. At 15-20 mm proximal to the severed level (level 1) of the left sciatic nerve, axonal atrophy with myelin cleft, myelin crenation, infolded loops of myelin and redundant loops of myelin was observed. Besides, there were a few fibers which presented so-called indirect Wallerian degeneration and the histogram of fiber diameter shifted toward the side of smaller diameter. 2. At the anterior root level (level 2 and 3), motor fibers of anterior root showed slight degree of myelin crenation and their mean diameter was 80%-90% of that of the control with its histogram preserving two peaks as in the unaffected anterior root. 3. At level 2 and 3, i. e. distal and proximal to the posterior root ganglion, many sensory nerve fibers showed myelin infolding and redundant loops of myelin with marked increase of small-sized fibers with resultant decrease of mean diameter to 60-70% of that of the control and the histogram of sensory nerve diameters shifted markedly toward the side of smaller diameter.
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| 9.
論文(リポジトリ) |
論文(リポジトリ)
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牧, 裕
概要:
The purpose of this study is to investigate the morphological changes of proximal and distal segment of severed proper digital nerves at different time lapses and the influence of these changes on axonal regeneration after
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reconnection of severed stumps. Proper digital nerves of fingers and toes of adult Japanese monkeys were used. Every proper digital nerve on one side was divided at the base of a digit, and both stumps were ligated to prevent spontaneous reconnection, while contralateral proper digital nerve was kept intact. Exp. A-1: Morphological changes of myelinated axon of severed proximal segment of toe were investigated. Exp. A-2: Proximal segments were sutured at 3, 6, and 12 months after severance, to freshly severed distal segment of contralateral proper digital nerve. Regeneration of myelinated axons were investigated. Exp. B-1: Morphological changes of Schwann tube of severed distal segment were investigated. Exp. B-2: Distal segment of proper digital nerves of fingers was sutured at 3, and 12 months after severance, to freshly severed proximal segment of contralateral proper digital nerves. Regeneration of myelinated axon was investigated. Percent of area, density and mean diameter of myelinated axons or Schwann tubes were measured and following results were obtained. (1) Myelinated axons of severed proximal segment shrank more with prolonged time after nerve severance. (2) Capacity of sprouting and maturation of regenerating axons of proximal segment significantly decreased when nerve was kept severed for more than 3 months. This can be one of the factors of impairment of axonal regeneration when the suture of a severed nerve delays more than 3 months after its severance. (3) Schwann tubes of the distal segment of a severed nerve shrank so slowly that its influence on axonal regeneration was much less, if sutured within 1 year, than shrinkage of myelinated axons of proximal segment which was kept severed for more than 3 months.
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| 10.
図書 |
図書
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田川宏 [ほか] 著
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