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論文(リポジトリ) |
論文(リポジトリ)
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樋口, 宗史
概要:
It is an unsolved question how the neuron－specific genes are . regulated in the mature neurons. The neuronal regulation
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of neuropeptide Y （NPY） gene which is a cotransmitter of sympathetic neurons and expressed abundantly in the central nervous system. The regulation of this gene resembles that of tyrosine hydroxylase gene.Both the membrane depolarization induced by neural activity and neurotrophic factors such as NGF induced the transcriptiional activation of NPY and enkephalin genes. These mechanisms are due to both Ca/almodulin and MAPK （mitogen－activated protein kinase） dependent processes, respectively. These findings indicated that the transcriptional activations of neural genes are due to the novel transactivational mechanisms. The novel transcriptional factors will be reported.
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| 2.
論文(リポジトリ) |
論文(リポジトリ)
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石黒, 淳司 ; 木村, 元政
概要:
Nuclear cardiology developed from estimation of regional myocardial perfusion, ventricular function and wall motion. Rec
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ently we have new three myocardial imaging agents, ^<123>I-metaiodobenzylguanedine (MIBG) is taken up by sympathetic nerve ending and provides a scintigraphic image of myocardial sympathetic innervation, β-methyl-p-(^<123>I)-iodophenyl-pentadecanoic acid (＾<123>I-BMIPP) radiopharmaceutically developed for the evaluation of myocardial fatty acid metabolism, ＾<99m>Tc-hexakis 2-methoxy isobutyl isonitrile (＾<99m>Tc-MIBI) not only provides regional myocardial perfusion but also estimates cardiac function and wall motion. In other side we have to new equipment that is able to be more sensitivity and specificity. Triangular (three-head) SPECT system and SIM 400 was developed. These new cardiac imaging agents and equipment was usefulness for nuclear cardiology in the future.
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