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論文(リポジトリ)

論文(リポジトリ)
Tatebe, Shoh ; Yoshimura, Takao ; Ohtani, Shin-ichi ; Kobayashi, Takashi
出版情報: Acta medica et biologica = Acta medica et biologica.  42  pp.35-38,  1994-03.  Niigata University School of Medicine
本文リンク: http://hdl.handle.net/10191/33237
概要: A case of a 65-year-old man with isolated iliac artery aneurysms presenting constipation is reported. The diagnosis of bilateral iliac aneurysm was made by computed tomography (CT) and arteriography. Three-dimensional CT was useful in making a definitive diagnosis. Surgical treatment included Y grafting and right internal iliac artery reconstruction. The literature on this subject is also reviewed. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
Matsuda, Yasunobu ; Wakai, Toshifumi ; Hirose, Yuki ; Sakata, Jun ; Kobayashi, Takashi ; Osawa, Mami ; Fujimaki, Shun ; Kubota, Masayuki
出版情報: 新潟大学保健学雑誌 = 新潟大学保健学雑誌.  11  pp.39-49,  2014-03.  新潟大学医学部保健学科
本文リンク: http://hdl.handle.net/10191/38942
概要: Background & Aims: The therapeutic potential of marrow stem cells for liver disease is currently unclear. The aim of thi s study was to investigate whether potentiating the chemotaxis ability of stromal cell-derived factor 1 could augment the engraftment of marrow stem cells and ameliorate tissue damage. Methods: Female mice reconstructed with β-galactosidase-positive male marrow cells were repeatedly injected with carbon tetrachloride to induce liver cirrhosis. The statuses of stromal cell-derived factor 1 and its inhibitor CD26 were examined by immunohistochemical staining, enzyme-linked immunosorbent assays and colorimetric assays. Recipients were treated with an inhibitory peptide for CD26(Diprotin A)together with granulocyte colony-stimulating factor, and the marrow-derived cells were tracked through the β-galactosidase activity or sex-determining region on the Y chromosome. Results: Stromal cell-derived factor 1 expression and CD26 activity were both significantly increased and marrow-derived hepatocytes were not observed in liver cirrhosis, suggesting that the potential of stem cell homing is impaired by liver damage. Granulocyte colony-stimulating factor only induced a few cell clusters comprising 2-6 marrow-derived hepatocytes at a late stage of liver cirrhosis. In contrast, when animals with liver cirrhosis were treated with Diprotin A after granulocyte colonystimulating factor-induced stem cell mobilization, marrow-derived hepatocytes increased to 2-4% of the total hepatocytes and both the serum albumin and hepatic hydroxyproline contents were ameliorated(p < .05). Conclusions: Maintaining the chemotaxis ability of stromal cell-derived factor 1 may represent an effective strategy for validating stem cell therapy. 続きを見る