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5)B型・C型肝炎ウイルス感染症の変貌と非ABCDE型肝炎ウイルス, GBウイルスの発見(シンポジウム STDの現状と対策, 第513回新潟医学会)

フォーマット:
論文(リポジトリ)
責任表示:
小方, 則夫
出版情報:
新潟医学会, 1996-12
掲載情報:
新潟医学会雑誌 = 新潟医学会雑誌
ISSN:
00290440  CiNii Articles  Webcat Plus  JAIRO
著者名:
小方, 則夫  
巻:
110
通号:
12
開始ページ:
556
終了ページ:
565
バージョン:
publisher
概要:
After eradication of posttransfusion hepatiis B and C, we are confronted with sporadic occurrence of viral hepatitis. Epidemiological studies indicate that hepatitis B is likely to be a sexually transmitted disease(STD), but hepatitis C is not. Incidence of the establishment of the infection largely depends on the virus amount of the index cases. Therefore, examination of virus amount of carries is likely to be the most important predictor of the infection. At present a goal of control of hepatitis B and C is to prevent the occurrence of fulminant hepatitis B and chronic hepatitis C, because the both are occasionally fatal. Our molecular studies suggest that the genetic mutation of the core promoter region of HBV would be one virus factor for the development of fulminant hepatitis B and that the presence of the hypervariable region of HCV might be one virus factor for the establishment of chronic hepatitis C. However, these findings have not yet directly utilized in the clinical fields. Hepatitis GB virus, originally known as the GB hepatitis agent, is recently molecularly cloned. The GB virus seems to belong to Family Flaviviridae and actually exists in humans including patients with non-ABCDE hepatitis. Since etiology of 20% of patients with possible virus hepatitis is unknown, hepatitis GB virus would partly account for the cause of these diseases. An essential strategy for prevention of virus infection is undoubtedly the primordial prevention. For the prevention of STD by hepatitis viruses social education is needed as in the case of AIDS. 続きを見る
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