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B型肝炎ウィルスの母子間垂直感染予防に関する臨床的研究 : 抗HB人免疫グロブリン, B型肝炎ワクチン併用投与による能動免疫獲得効果について

フォーマット:
論文(リポジトリ)
責任表示:
大桃, 幸夫
出版情報:
新潟医学会, 1989-08
掲載情報:
新潟医学会雑誌 = 新潟医学会雑誌
ISSN:
00290440  CiNii Articles  Webcat Plus  JAIRO
著者名:
大桃, 幸夫  
巻:
103
通号:
8
開始ページ:
644
終了ページ:
651
バージョン:
publisher
概要:
Efficacy and rationale of our scheduled protocol were studied, as to a measure for prevention of vertical HBvirus transmission to the babies. We examined on 70 babies whose mother were positive for HBsAg and HBeAg. The protocol was administration of HB-immunoglobulin (HBIG) within 48 hours after birth when the umbilical cord serum was negative for HBsAg, followed by vaccination with inactivated HB-virus for three times at 2 months, 3 months and 5 months after birth. The results obtained are as follows; 1. Three cases out of 70 became HB-carriers by 2 months after birth, although HBIG was administerd to the cases. Out of remaining 67 cases treated as scheduled, one became HB-carrier at 1 year old and another one case became transiently positive for HBsAg at 7 months after birth. Sixty-five cases out of the 70 babies (92.9%) were thus successfully prevented from being HB-carrier. 2. In these 65 cases, times of the vaccination necessary for acquiring active immunity were analyzed. Fifty-four cases out of 65 infants (85.1%) gained sufficient anti-HBsAb titer (titer of 2^2) by 2 to 3 times of vaccination, and 9 cases (13.8%) by 4 times of vaccination. Two cases (4.6%), however, rembined to be negative for HBsAb even after 4 times of vaccination. 3. The titer of serum anti-HBsAb was serially examined by passive hemagglutinin (PHA) method in 46 cases who have been followed up for more than 12 months after birth. In more than 50% of the cases who had produced sufficient anti-HBs at 6th or 8th month, significantly high titer of anti-HBs was found to persist 24th month after the birth. 4. The mean value of anti-HBs antibody titer at 6th or 8th month after birth was 2^<3.6> and the half life of anti HBs-titer in the babies was estimated to be 12.65 month. These data strongly suggested that the protocol adopted in this study was an effective and rational one for preventing the vertical transmission of HB-virus from mothers positive for HBeAg to the babies. It was also confirmed that the amount of anti-HBs antibody produced under this protocol regimen persisted at least as long as the 24th month after birth. 続きを見る
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